D-myo-Inositol-2,3,4,5-tetraphosphate (ammonium salt)
Item № 10008456
Purity ≥98%
100 µg $110.00 $0.00
500 µg $495.00 $0.00
1 mg $880.00 $0.00

Pricing updated 2016-05-05. Prices are subject to change without notice.

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  • Ins(2,3,4,5)-P4 (ammonium salt)
  • 2,3,4,5-IP4 (ammonium salt)

D-myo-Inositol-2,3,4,5-tetraphosphate (Ins(2,3,4,5)-P4) is a member of the inositol phosphate (InsP) family of molecules that play a critical role as small, soluble second messengers in the transmission of cellular signals.1,2 The most studied InsP, Ins(1,4,5)-P3, more commonly referred to as IP3, is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidyl inositol-4,5-biphosphate.3,4 Binding of Ins(1,4,5)-P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intracellular calcium.4,5

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Technical Information
Formal Name D-myo-inositol-2,3,4,5-tetra(hydrogen phosphate), tetraammonium salt
  • Ins(2,3,4,5)-P4 (ammonium salt)
  • 2,3,4,5-IP4 (ammonium salt)
Molecular Formula C6H12O18P4 · 4NH4
Formula Weight 568.2
Purity ≥98%
Formulation A lyophilized powder
SMILES O[C@H]1[C@H](O)[C@@H](OP([O-])(O)=O)[C@H](OP([O-])(O)=O)[C@@H](OP([O-])(O)=O)[C@H]1OP([O-])(O)=O.[NH4+].[NH4+].[NH4+].[NH4+]
InChI Code 1S/C6H16O18P4.4H3N/c7-1-2(8)4(22-26(12,13)14)6(24-28(18,19)20)5(23-27(15,16)17)3(1)21-25(9,10)11;;;;/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20);4*1H3/t1-,2-,3?,4?,5?,6?;;;;/m0..../s1

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability As supplied, 1 year from the QC date provided on the Certificate of Analysis, when stored properly
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Additional Information

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References & Background Reading
Product Description References

1. Berridge, M.J. Inositol trisphosphate and calcium signalling. Nature 361 315-325 (1993).

2. Majerus, P.W. Inositol phosphate biochemistry. Annu Rev Biochem 61 225-250 (1992).

3. Streb, H., Irvine, R.F., Berridge, M.J., et al. Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate. Nature 306 67-69 (1983).

4. Yoshida, Y., and Imai, S. Structure and function of inositol 1,4,5-triphosphate receptor. Jpn J Pharmacol 74 125-137 (1997).

5. Exton, J.H. Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins. Annu Rev Pharmacol Toxicol 36 481-509 (1996).

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