Propylpyrazole Triol
Item № 10008841
CAS № 263717-53-9
Purity ≥98%
1 mg $16.00 $0.00
5 mg $72.00 $0.00
10 mg $128.00 $0.00
25 mg $280.00 $0.00

Pricing updated 2016-05-04. Prices are subject to change without notice.

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  • PPT

Estrogen receptor α (ERα) and ERβ are ligand-activated transcription factors that mediate the actions of estrogen. Activation of ERα, but not ERβ, is required for the cardioprotective effects of estradiol. Propylpyrazole triol (PPT) is an ERα selective agonist with a 410-fold relative binding affinity for ERα (49%) versus ERβ (0.12%) and therefore activates gene transcription only through ERα.1,2 In an in vivo rabbit model of ischemia-reperfusion injury, treatment with estradiol and PPT, but not diarylpropinitrile (a selective agonist of ERβ) significantly decreased the infarct size compared with vehicle.3

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Technical Information
Formal Name 4,4',4''-(4-propyl-1H-pyrazole-1,3,5-triyl)tris-phenol
CAS Number 263717-53-9
  • PPT
Molecular Formula C24H22N2O3
Formula Weight 386.4
Purity ≥98%
Formulation A crystalline solid
λmax 255 nm
InChI Code 1S/C24H22N2O3/c1-2-3-22-23(16-4-10-19(27)11-5-16)25-26(18-8-14-21(29)15-9-18)24(22)17-6-12-20(28)13-7-17/h4-15,27-29H,2-3H2,1H3

WARNING - This product is not for human or veterinary use.

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Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
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References & Background Reading
Product Description References

1. Stauffer, S.R., Coletta, C.J., Tedesco, R., et al. Pyrazole ligands: Structure-affinity/activity relationships and estrogen receptor-.alpha.-selective agonists. J Med Chem 43 4934-4947 (2000).

2. Meyers, M.J., Sun, J., Carlson, K.E., et al. Estrogen receptors-.beta. potency-selective ligands: Structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogus. J Med Chem 44 4230-4251 (2001).

3. Booth, E.A., Obeid, N.R., and Lucchesi, B.R. Activation of estrogen receptor-.alpha. protects the in vivo rabbit heart from ischemia-reperfusion injury. Am J Physiol 289 H2039-H2047 (2005).

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