Item № 10009557
CAS № 839707-37-8
Purity ≥98%
1 mg $45.00 $0.00
5 mg $124.00 $0.00
10 mg $225.00 $0.00
25 mg $495.00 $0.00

Pricing updated 2016-05-25. Prices are subject to change without notice.

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  • Pluripotin

The maintenance of embryonic stem cells in culture typically requires feeder cells and various exogenous factors found in serum. Murine embryonic stem (mES) cells can be maintained in the absence of feeder cells and serum but require the leukemia inhibitor factor (LIF) and bone morphogenic protein (BMP) to prevent differentiation and promote self-renewal. SC-1 is a small molecule activator of stem cell renewal that allows the propagation of OG2 mES cells for at least 10 passages in an undifferentiated state.1 The activity of SC-1 is mediated by the combined inhibition of RasGAP and ERK1 with Kd values of 98 and 212 nM, respectively.1 Inhibition of Ras-GAP increases Ras signaling via the PI3-kinase pathway which promotes self-renewal, whereas inhibition of ERK blocks differentiation.

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Technical Information
Formal Name N-(3-(7-(1,3-dimethyl-1H-pyrazol-5-ylamino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide
CAS Number 839707-37-8
  • Pluripotin
Molecular Formula C27H25F3N8O2
Formula Weight 550.5
Purity ≥98%
Formulation A crystalline solid
SMILES Cc1nn(C)c(Nc2ncc3CN(c4cc(ccc4C)NC(=O)c4cccc(c4)C(F)(F)F)C(=O)N(C)c3n2)c1
InChI Code 1S/C27H25F3N8O2/c1-15-8-9-20(32-24(39)17-6-5-7-19(11-17)27(28,29)30)12-21(15)38-14-18-13-31-25(34-23(18)36(3)26(38)40)33-22-10-16(2)35-37(22)4/h5-13H,14H2,1-4H3,(H,32,39)(H,31,33,34)

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
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References & Background Reading
Product Description References

1. Chen, S., Do, J.T., Zhang, Q., et al. Self-renewal of embryonic stem cells by a small molecule. Proc Natl Acad Sci USA 103(46) 17266-17271 (2006).

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