GW 590735
Item № 10009880
CAS № 622402-22-6
Purity ≥98%
1 mg $43.00 $0.00
5 mg $194.00 $0.00
10 mg $344.00 $0.00
25 mg $753.00 $0.00

Pricing updated 2016-05-26. Prices are subject to change without notice.

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The peroxisome proliferator-activated receptors (PPARs) α, γ, and δ are ligand-activated transcription factors that play a key role in lipid homeostasis. Activation of PPARα results in increased clearance of triglyceride (TG) rich very low-density lipoprotein (VLDL) via a reduction in plasma levels of ApoCIII and in upregulation of ApoA1, the principal lipoprotein component of HDL.1 GW 590735 is a potent and selective agonist of PPARα with an EC50 value of 4 nM for the expression a GAL4-responsive reporter gene and at least 500-fold selectivity versus PPARγ and PPARδ.1

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Technical Information
Formal Name 2-methyl-2-(4-((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-carboxamido)methyl)phenoxy)propanoic acid
CAS Number 622402-22-6
Molecular Formula C23H21F3N2O4S
Formula Weight 478.5
Purity ≥98%
Formulation A crystalline solid
λmax 224, 311 nm
SMILES O=C(NCc1ccc(cc1)OC(C)(C)C(=O)O)c1sc(nc1C)c1ccc(cc1)C(F)(F)F
InChI Code 1S/C23H21F3N2O4S/c1-13-18(33-20(28-13)15-6-8-16(9-7-15)23(24,25)26)19(29)27-12-14-4-10-17(11-5-14)32-22(2,3)21(30)31/h4-11H,12H2,1-3H3,(H,27,29)(H,30,31)

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
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References & Background Reading
Product Description References

1. Sierra, M.L., Beneton, V., Boullay, A., et al. Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPAR.alpha. agonists. 1. Discovery of a novel series of potent HDLc raising agents. J Med Chem 50 685-695 (2007).

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