Item № 10010340
CAS № 73573-88-3
Purity ≥98%
5 mg $20.00 $0.00
10 mg $36.00 $0.00
25 mg $55.00 $0.00
50 mg $64.00 $0.00

Pricing updated 2016-04-30. Prices are subject to change without notice.

Bulk Inquiry Form


Enter number, size, and select unit. Example: 2 x 500 mg

Please indicate any analytical testing requirements, special handling, packaging, or delivery requirements.

  • Compactin
  • CS 500
  • L 637312
  • ML 236B
  • NSC 281245
  • Statin I

HMG-CoA reductase is the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the “statin” class of cholesterol-lowering drugs.1 Mevastatin is a HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum. It inhibits HMG-CoA reductase in a reversible and competitive manner with a Ki value of 1 nM for the open ring acid form of the molecule.2 During a 24 week study period, a dose of 30 mg/day mevastatin reduced plasma LDL-cholesterol approximately 29% in patients with familial hypercholesterolemia.2 Mevastatin also suppresses TNF-induced NF-κB activation (IC50 = ~17 µM), which potentiates apoptosis in human myeloid leukemia cells and thus, may be useful in treating cancer.3

Download Product Insert Download Safety Data Sheet (SDS)

Related Products
View Related Product Categories
Technical Information
Formal Name 2S-methyl-(1S,2,3,7S,8S,8aR)-hexahydro-7-methyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2-H-pyran-2-yl]ethyl]-1-naphthalenyl ester-butanoic acid
CAS Number 73573-88-3
  • Compactin
  • CS 500
  • L 637312
  • ML 236B
  • NSC 281245
  • Statin I
Molecular Formula C23H34O5
Formula Weight 390.5
Purity ≥98%
Formulation A crystalline solid
SMILES CC[C@H](C)C(=O)O[C@H]1CCC=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)C12
InChI Code 1S/C23H34O5/c1-4-14(2)23(26)28-20-7-5-6-16-9-8-15(3)19(22(16)20)11-10-18-12-17(24)13-21(25)27-18/h6,8-9,14-15,17-20,22,24H,4-5,7,10-13H2,1-3H3/t14-,15-,17+,18+,19-,20-,22?/m0/s1

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Product Downloads & Resources
Product Downloads

Download Product Insert

Download Safety Data Sheet (SDS)

Download free InChI Key generation software

Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

Get Batch-Specific Data and Documents by Batch Number

Separate multiple batch numbers with commas

QC Sheets
Certificates of Analysis
References & Background Reading
Product Description References

1. Tobert, J.A. Lovastatin and beyond: The history of the HMG-CoA reductase inhibitors. Nat Rev Drug Discov 2 517-526 (2003).

2. Endo, A. The discovery and development of HMG-CoA reductase inhibitors. J Lipid Res 33 1569-1582 (1992).

3. Ahn, K.S., Sethi, G., and Aggarwal, B.B. Reversal of chemoresistance and enhancement of apoptosis by statins through down-regulation of the NF-.kappa.B pathway. Biochem Pharmacol 75 907-913 (2008).

Technical Support
Contact Us
  • To streamline the process attach the appropriate questionnaire to your inquiry.

  • Toll Free Phone (USA and Canada Only): (888) 526-5351
  • Direct Phone: (734) 975-3888
Contract Research Services

We offer you the deep and diverse knowledge of more than 100 in-house scientists and the expertise that comes from more than three decades of designing and developing the tools to advance biomedical research.

Cayman is know as a partner to scientists worldwide, responding to your needs with services in:

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA