15-Lipoxygenase Inhibitor 1
Item № 10010468
CAS № 928853-86-5
Purity ≥95%
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500 µg $25.00 $0.00
1 mg $48.00 $0.00
5 mg $200.00 $0.00
10 mg $350.00 $0.00

Pricing updated 2016-05-24. Prices are subject to change without notice.

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Description
Synonyms
  • 15-LO Inhibitor 1

Lipoxygenases (LOs) are non-heme iron-containing dioxygenases that catalyze the oxidation of polyunsaturated fatty acids to generate unsaturated fatty acid hydroperoxides.1 The immediate products of 15-LO fatty acid oxidation act as mediators in inflammation, thrombosis, and cancer.2 15-Lipoxygenases (15-LO) inhibitor 1 is a heterocyclic pyrimidobenzothiazine compound that inhibits 15-LO with an IC50 value of 18 µM.3 The inhibitor appears to act as an antioxidant, interfering with the redox cycle of 15-LO.3

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Technical Information
Formal Name 4-methyl-2-(4-methylpiperazinyl)pyrimido[4,5-b]benzothiazine
CAS Number 928853-86-5
Synonyms
  • 15-LO Inhibitor 1
Molecular Formula C16H19N5S
Formula Weight 313.4
Purity ≥95%
Formulation A crystalline solid
λmax 323, 255, 221 nm
SMILES Cc1nc(nc2Sc3ccccc3Nc12)N1CCNCC1
InChI Code 1S/C16H19N5S/c1-11-14-15(22-13-6-4-3-5-12(13)18-14)19-16(17-11)21-9-7-20(2)8-10-21/h3-6,18H,7-10H2,1-2H3
InChI Key HYPHGMNLWIKEMB-UHFFFAOYSA-N

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability As supplied, 1 year from the QC date provided on the Certificate of Analysis, when stored properly
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References & Background Reading
Product Description References

1. Gaffney, B.J. Lipoxygenases: Structural principles and spectroscopy. Annu Rev Biophys Biomol Struct 25 431-459 (1996).

2. Chanez, P., Bonnans, C., Chavis, C., et al. 15-Lipoxygenase. A janus enzyme? Am J Respir Cell Mol Biol 27 655-658 (2002).

3. Bakavoli, M., Nikpour, M., Rahimizadeh, M., et al. Design and synthesis of pyrimido[4,5-b][1,4]benzothiazine derivatives, as potent 15-lipoxygenase inhibitors. Bioorg Med Chem 15 2120-2126 (2007).

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