Pricing updated 2016-02-14. Prices are subject to change without notice.
Papaverine is an opium alkaloid that is structurally and pharmacologically distinct from opiates. At the cellular level, papaverine inhibits phosphodiesterase activity (IC50 = 13 μM).1 Through this action, it increases cellular cAMP levels and alters cellular function. It has been shown to reduce arterial and cerebral vasospasm2,3 and has been used to treat erectile dysfunction.4,5 Papaverine is recommended as a potent nonselective phosphodiesterase inhibitor for in vitro and in vivo research purposes.
|Formulation||A crystalline solid|
WARNING - This product is not for human or veterinary use.
|Shipping||Room temperature in continental US; may vary elsewhere|
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Davis, C.W. Assessment of selective inhibition of rat cerebral cortical calcium-
2. Vardiman, A.B., Kopitnik, T.A., Purdy, P.D., et al. Treatment of traumatic arterial vasospasm with intraarterial papaverine infusion. AJNR Am J Neuroradiol 16 319-321 (1995).
3. Clouston, J.E., Numaguchi, Y., Zoarski, G.H., et al. Intraarterial papaverine infusion for cerebral vasospasm after subarachnoid hemorrhage. AJNR Am J Neuroradiol 16 27-38 (1995).
Virag, R., Shoukry, K., Floresco, J., et al. Intracavernous self-
5. Earle, C.M., Keogh, E.J., Wisniewski, Z.S., et al. Prostaglandin E1 therapy for impotence, comparison with papaverine. J Urol 143 57-59 (1990).
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