N-butyryl-L-Homocysteine thiolactone
Item № 10011204
CAS № 202284-85-3
Purity ≥95%
5 mg $26.00 $0.00
10 mg $49.00 $0.00
25 mg $117.00 $0.00
50 mg $208.00 $0.00

Pricing updated 2016-04-30. Prices are subject to change without notice.

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Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. Controlling bacterial infections by quenching their quorum sensing systems is a promising field of study. The expression of specific target genes, such as transcriptional regulators belonging to the LuxIR family of proteins, is coordinated by synthesis of diffusible acylhomoserine lactone (AHL) molecules. N-butyryl-L-Homocysteine thio-lactone is an analog of N-butyryl-L-homoserine lactone, the small diffusible signaling molecule involved in quorum sensing, thereby controlling gene expression and cellular metabolism.1 N-butyryl-L-Homocysteine thio-lactone induces violacein expression in C. violaceum mutants usually not able to produce AHLs.1,2

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Technical Information
Formal Name N-[(3S)-tetrahydro-2-oxo-3-thienyl]-butanamide
CAS Number 202284-85-3
Molecular Formula C8H13NO2S
Formula Weight 187.3
Purity ≥95%
Formulation A crystalline solid
InChI Code 1S/C8H13NO2S/c1-2-3-7(10)9-6-4-5-12-8(6)11/h6H,2-5H2,1H3,(H,9,10)/t6-/m0/s1

WARNING - This product is not for human or veterinary use.

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Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
Stability As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
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References & Background Reading
Product Description References

1. Ikeda, T., Kajiyama, K., Kita, T., et al. The synthesis of optically pure enantiomers of N-acyl-homoserine lactone autoinducers and their analogues. Chem Lett 314-315 (2001).

2. McClean, K.H., Winson, M.K., Fish, L., et al. Quorum-sensing and Chromobacterium violaceum: Exploitation of violacein production and inhibition for the detection of N-acylhomoserine lactones. Microbiology 143 3703-3711 (1997).

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