Pricing updated 2016-05-05. Prices are subject to change without notice.
Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulates genes involved in lipid metabolism.1 They are also inherently cytotoxic, as physiological imbalance contributes to increased oxidative stress.2,3 Bile acid-
|Formulation||A crystalline solid|
WARNING - This product is not for human or veterinary use.
|Shipping||Room temperature in continental US; may vary elsewhere|
|Stability||As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly|
View the Cayman Structure Database for chemical structure definitions for many Cayman products
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1. Makishima, M., Okamoto, A.Y., Repa, J.J., et al. Identification of a nuclear receptor for bile acids. Science 284 1362-1365 (1999).
2. Barbier, O., Torra, I.P., Sirvent, A., et al. FXR induces the UGT2B4 enzyme in hepatocytes: A potential mechanism of negative feedback control of FXR activity. Gastroenterology 124 1926-1940 (2003).
Tan, K.P., Yang, M., and Ito, S. Activation of nuclear factor (erythroid-
4. Urizar, N.L., Liverman, A.B., Dodds, D.T., et al. A natural product that lowers cholesterol as an anatagonist ligand for FXR.. Science 296 1703-1706 (2002).
5. Cui, J., Huang, L., Zhao, A., et al. Guggulsterone is a farnesoid X receptor antagonist in coactivator association assays but acts to enhance transcription of bile salt export pump. J Biol Chem 278(12) 10214-10220 (2003).
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