Item № 10043
CAS № 85026-51-3
Purity ≥97%
500 µg $88.00 $0.00
1 mg $167.00 $0.00
5 mg $704.00 $0.00
10 mg $1,232.00 $0.00

Pricing updated 2016-05-02. Prices are subject to change without notice.

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Iloprost is a second generation structural analog of prostacyclin (PGI2) with about ten-fold greater potency than the first generation stable analogs, typified by carbaprostacyclin.1 Iloprost binds with equal affinity to the recombinant human IP and EP receptors with a Ki of 11 nM.2 15(R)-Iloprost is the “unnatural” or inverted C-15 epimer of iloprost. This transformation frequently attenuates the biological agonist activity of prostaglandin analogs by several orders of magnitude. There are no literature reports of the biological activity of 15(R)-iloprost.

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Technical Information
Formal Name 6,9α-methylene-11α,15R-dihydroxy-16-methyl-prosta-5E,13E-dien-18-yn-1-oic acid
CAS Number 85026-51-3
Molecular Formula C22H32O4
Formula Weight 360.5
Purity ≥97%
Formulation A solution in methyl acetate
SMILES O[C@H]1[C@H](/C=C/[C@H](O)C(C)CC#CC)[C@@H](C/C(C2)=C/CCCC(O)=O)[C@@H]2C1
InChI Code 1S/C22H32O4/c1-3-4-7-15(2)20(23)11-10-18-19-13-16(8-5-6-9-22(25)26)12-17(19)14-21(18)24/h8,10-11,15,17-21,23-24H,5-7,9,12-14H2,1-2H3,(H,25,26)/b11-10+,16-8+/t15?,17-,18+,19-,20-,21+/m0/s1

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability As supplied, 1 year from the QC date provided on the Certificate of Analysis, when stored properly
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Additional Information

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References & Background Reading
Product Description References

1. Schrör, K., Darius, H., Matzky, R., et al. The antiplatelet and cardiovascular actions of a new carbacyclin derivative (ZK36374) - equipotent to PGI2 in vitro. Naunyn Schmiedebergs Arch Pharmacol 316 252-255 (1981).

2. Abramovitz, M., Adam, M., Boie, Y., et al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta 1483 285-293 (2000).

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