Histone H4 (human recombinant)
Item № 10264
Purity ≥95% estimated by SDS-PAGE
1 mg $350.00 $0.00

Pricing updated 2016-05-03. Prices are subject to change without notice.

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  • H4
  • Histone H4

A nucleosome is the basic repeating unit of chromatin in which 146 base pairs of DNA wrap twice around a histone octamer consisting of two copies of each of the core histones, H2A, H2B, H3, and H4.1 The combination of two H2A/H2B dimers and one H3/H4 tetramer create the nucleosome core.2 Histone H4 undergoes many modifications which include acetylation, methylation, and phosphorylation that are important for regulation of gene transcription.1

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Technical Information
  • H4
  • Histone H4
Purity ≥95% estimated by SDS-PAGE
Source Recombinant protein expressed in E. coli
Amino Acids Amino acids 1-103 (full-length)
MW 11.5 kDa
Formulation A lyophilized powder; recommended buffer for reconstitution is 50 mM sodium phosphate, pH 7.2, containing 100 mM sodium chloride and 20% glycerol.
UniProt Accession № P62805

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere
Stability As supplied, 6 months from the QC date provided on the Certificate of Analysis, when stored properly
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References & Background Reading
Product Description References

1. Bhaumik, S.R., Smith, E., and Shilatifard, A. Covalent modifications of histones during development and disease pathogenesis. Nat Struct Mol Biol 14(11) 1008-1016 (2007).

2. Tanaka, Y., Tawaramoto-Sasanuma, M., Kawaguchi, S., et al. Expression and purification of recombinant human histones. Methods 33 3-11 (2004).

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