EUK 118
Item № 10271
CAS № 186299-34-3
Purity ≥95%
5 mg $25.00 $0.00
10 mg $48.00 $0.00
50 mg $200.00 $0.00
100 mg $350.00 $0.00

Pricing updated 2016-04-29. Prices are subject to change without notice.

Bulk Inquiry Form


Enter number, size, and select unit. Example: 2 x 500 mg

Please indicate any analytical testing requirements, special handling, packaging, or delivery requirements.


EUK 8 and EUK 134 (Item No. 10006329) are synthetic catalytic scavengers of reactive oxygen species with superoxide dismutase (SOD) and catalase mimetic activity.1 EUK 118 is a structural analog of EUK 8 and EUK 134 with significantly reduced activity. EUK 118 exhibits a catalase activity of 35 µM O2 formed/minute from 10 mM hydrogen peroxide, which is more than four times lower that that observed for EUK 8 under the same conditions.2 Superoxide-mediated reduction of an electron acceptor (i.e., SOD mimetic activity) was inhibited by EUK 118 and EUK 8 with IC50 values of 2 and 0.7 µM, respectively. EUK 118 did not protect human dermal fibroblasts against hydrogen peroxide-induced cell death.2

Download Product Insert Download Safety Data Sheet (SDS)

Related Products
View Related Product Categories
Technical Information
Formal Name (acetato-κO)[[2,2'-[1,2-ethanediylbis[(nitrilo-κN)methylidyne]]bis[3,5-dimethoxyphenolato-κO]](2-)]-manganese
CAS Number 186299-34-3
Molecular Formula C22H25MnN2O8
Formula Weight 500.4
Purity ≥95%
Formulation A crystalline solid
SMILES CC([O-][Mn]123([N](CC[N]2=CC4=C(OC)C=C(OC)C=C4[O-]3)=CC5=C(OC)C=C(OC)C=C5[O-]1)[Mn][Mn+])=O
InChI Code 1S/C20H24N2O6.C2H4O2.3Mn/c1-25-13-7-17(23)15(19(9-13)27-3)11-21-5-6-22-12-16-18(24)8-14(26-2)10-20(16)28-4;1-2(3)4;;;/h7-12,23-24H,5-6H2,1-4H3;1H3,(H,3,4);;;/q;;;;+1/p-3/b21-11+,22-12+;;;;

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Product Downloads & Resources
Product Downloads

Download Product Insert

Download Safety Data Sheet (SDS)

Download free InChI Key generation software

Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

Get Batch-Specific Data and Documents by Batch Number

Separate multiple batch numbers with commas

QC Sheets
Certificates of Analysis
References & Background Reading
Product Description References

1. Baker, K., Marcus, C.B., Huffman, K., et al. Synthetic combined superoxide dismutase/catalase mimetics are protective as a delayed treatment in a rat stroke model: A key role for reactive oxygen species in ischemic brain injury. J Pharmacol Exp Ther 284(1) 215-221 (1998).

2. Doctrow, S.R., Huffman, K., Marcus, C.B., et al. Salen-manganese complexes as catalytic scavengers of hydrogen peroxide and cytoprotective agents: Structure-activity relationship studies. J Med Chem 45 4549-4558 (2002).

Technical Support
Contact Us
  • To streamline the process attach the appropriate questionnaire to your inquiry.

  • Toll Free Phone (USA and Canada Only): (888) 526-5351
  • Direct Phone: (734) 975-3888
Contract Research Services

We offer you the deep and diverse knowledge of more than 100 in-house scientists and the expertise that comes from more than three decades of designing and developing the tools to advance biomedical research.

Cayman is know as a partner to scientists worldwide, responding to your needs with services in:

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA