16,16-dimethyl Prostaglandin A2
Item № 10280
CAS № 41691-92-3
Purity ≥98%
1 mg $74.00 $0.00
5 mg $333.00 $0.00
10 mg $592.00 $0.00

Pricing updated 2016-05-25. Prices are subject to change without notice.

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  • 16,16-dimethyl PGA2

16,16-dimethyl PGA2 is a metabolism-resistant analog of PGA2 with a prolonged in vivo half-life. It inhibits the proliferation of Sendai virus in cultured African green monkey kidney cells by >90% at a concentration of 4 µg/ml.1 Daily infusion of 10 µg of 16,16-dimethyl PGA2 methyl ester into mice infected with influenza A virus increased survival by 40%.2 Similar treatment of mice inoculated with erythroleukemia cells delayed tumor growth and increased survival time.3

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Technical Information
Formal Name 9-oxo-15R-hydroxy-16,16-dimethyl-prosta-5Z,10,13E-trien-1-oic acid
CAS Number 41691-92-3
  • 16,16-dimethyl PGA2
Molecular Formula C22H34O4
Formula Weight 362.5
Purity ≥98%
Formulation A solution in methyl acetate
λmax 215 nm
SMILES O=C1[C@H](C/C=C\CCCC(O)=O)[C@@H](/C=C/[C@@H](O)C(C)(C)CCCC)C=C1
InChI Code 1S/C22H34O4/c1-4-5-16-22(2,3)20(24)15-13-17-12-14-19(23)18(17)10-8-6-7-9-11-21(25)26/h6,8,12-15,17-18,20,24H,4-5,7,9-11,16H2,1-3H3,(H,25,26)/b8-6-,15-13+/t17-,18-,20-/m1/s1

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability As supplied, 1 year from the QC date provided on the Certificate of Analysis, when stored properly
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References & Background Reading
Product Description References

1. Santoro, M.G., Benedetto, A., Carruba, G., et al. Prostaglandin A compounds as antiviral agents. Science 209 1032-1034 (1980).

2. Santoro, M.G., Favalli, C., Mastino, A., et al. Antiviral activity of a synthetic analog of prostaglandin A in mice infected with influenza A virus.. Arch Virol 99 89-100 (1988).

3. Marini, S., Palamara, A.T., Garaci, E., et al. Growth inhibition of friend erythroleukaemia cell tumours in vivo by a synthetic analogue of prostaglandin A: An action independent of natural killer-activity. Br J Cancer 61 394-399 (1990).

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