Item № 10497
CAS № 105517-82-6
Purity ≥98%
25 µg $98.00 $0.00
50 µg $186.00 $0.00
100 µg $353.00 $0.00

Pricing updated 2016-04-29. Prices are subject to change without notice.

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Very long chain polyunsaturated fatty acids (VLCPUFA) are present in retina, sperm, and brain.1,2,3 Though little is known of their biosynthesis or functional roles in these tissues, recent studies using the elongation of very long-chain FA-4 protein suggest a unique role for VLCPUFA in retinal development and macular degeneration.4,5 CAY10632 is a C32:6 VLCPUFA whose specific biological actions are largely unknown, but are thought to involve normal photoreceptor cell function in the retina.4,6

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Technical Information
Formal Name 14Z,17Z,20Z,23Z,26Z,29Z-dotriacontahexaenoic acid
CAS Number 105517-82-6
Molecular Formula C32H52O2
Formula Weight 468.8
Purity ≥98%
Formulation A solution in ethanol
InChI Code 1S/C32H52O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26-27-28-29-30-31-32(33)34/h3-4,6-7,9-10,12-13,15-16,18-19H,2,5,8,11,14,17,20-31H2,1H3,(H,33,34)/b4-3-,7-6-,10-9-,13-12-,16-15-,19-18-

WARNING - This product is not for human or veterinary use.

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Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
Stability As supplied, 1 year from the QC date provided on the Certificate of Analysis, when stored properly
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References & Background Reading
Product Description References

1. Aveldaño, M.I. Phospholipid species containing long and very long polyenoic fatty acids remain with rhodopsin after hexane extraction of photoreceptor membranes. Biochemistry 27 1229-1239 (1988).

2. Robinson, B.S., Johnson, D.W., and Poulos, A. Novel molecular species of spingomyelin containing 2-hydroxylated polyenoic very-long-chain fatty acids in mammalian testes and spermatozoa. J Biol Chem 267 1746-1751 (1992).

3. Robinson, B.S., Johnson, D.W., and Poulos, A. Unique molecular species of phophatidylcholine containing very-long-chain (C24-C38) polyenoic fatty acids in rat brain. Biochem J 265 763-7 (1990).

4. McMahon, A., Jackson, S.N., Woods, A.S., et al. A Stargardt disease-3 mutation in the mouse Elovl4 gene causes retinal deficiency of C32-C36 acyl phosphatidylcholines. FEBS Lett 581 5459-5463 (2007).

5. Agbaga, M., Mandal, M.N.A., and Anderson, R.E. Retinal very long-chain PUFAs: New insights from studies on ELOVL4 protein. J Lipid Res 51 1624-1642 (2010).

6. Agbada, M., Brush, R.S., Mandal, N.A., et al. Role of Stargardt-3 macular dystrophy protein (ELOVL4) in the biosynthesis of very long chain fatty acids. Proc Natl Acad Sci USA 105(35) 12843-8 (2008).

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