Item № 10532
CAS № 712313-33-2
Purity ≥95%
1 mg $43.00 $0.00
5 mg $194.00 $0.00
10 mg $344.00 $0.00
25 mg $753.00 $0.00

Pricing updated 2016-05-04. Prices are subject to change without notice.

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  • CAY10633

The cysteinyl leukotrienes LTC4 and LTD4 are potent mediators of asthma and hypersensitivity. They induce bronchoconstriction, increase microvascular permeability, and are vasoconstrictors of coronary arteries. Their biological effects are transduced by a pair of G-protein coupled receptors, CysLT1 and CysLT2.1,2,3 BayCysLT2 is a potent CysLT2 receptor antagonist that inhibits radioligand binding of LTD4 to CysLT2 and CysLT1 receptor cell lines with IC50 values of 35 and >10,000 nM, respectively.4 BayCysLT2 concentration-dependently reverses LTC4-stimulated perfusion pressure increase and contractility decrease in isolated Langendorff-perfused guinea pig hearts.4

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Technical Information
Formal Name 3-[[(3-carboxycyclohexyl)amino]carbonyl]-4-[3-[4-(4-phenoxybutoxy)phenyl]propoxy]-benzoic acid
CAS Number 712313-33-2
  • CAY10633
Molecular Formula C34H39NO8
Formula Weight 589.7
Purity ≥95%
Formulation A crystalline solid
InChI Code 1S/C34H39NO8/c36-32(35-27-10-6-9-25(22-27)33(37)38)30-23-26(34(39)40)15-18-31(30)43-21-7-8-24-13-16-29(17-14-24)42-20-5-4-19-41-28-11-2-1-3-12-28/h1-3,11-18,23,25,27H,4-10,19-22H2,(H,35,36)(H,37,38)(H,39,40)

WARNING - This product is not for human or veterinary use.

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Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
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References & Background Reading
Product Description References

1. Lynch, K.R., O'Neill, G.P., Liu, Q., et al. Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature 399 789-793 (1999).

2. Heise, C.E., O'Dowd, B.F., Figueroa, D.J., et al. Characterization of the human cysteinyl leukotriene 2 receptor. J Biol Chem 275 30531-30536 (2000).

3. Sarau, H.M., Ames, R.S., Chambers, J., et al. Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor. Mol Pharmacol 56 657-663 (1999).

4. Harter, M., Erguden, J., Wunder, F., et al. Isophtalic acid derivatives. 10/537,623 1-104 (2006 Jul 13).

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