4-pentynoyl-Coenzyme A (trifluoroacetate salt)
Item № 10547
Purity ≥95%
500 µg $60.00 $0.00
1 mg $114.00 $0.00
5 mg $480.00 $0.00
10 mg $840.00 $0.00

Pricing updated 2016-04-30. Prices are subject to change without notice.

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  • Click Tag™ 4-pentynoyl-CoA

Protein acetylation is a reversible, post-translational modification regulated by lysine acetyltransferases and deacetylases and plays a key role in regulating gene expression. 4-pentynoyl-Coenzyme A (trifluoroacetate salt) (4-pentynoyl-CoA (trifluoroacetate salt)) is an alkyne-derivatized acetyl-CoA reporter that enables rapid detection of acetylated proteins both in vivo and in vitro.1 As an acyl-CoA donor, the 4-pentynoyl analog is metabolically transferred onto lysine residues of proteins by lysine acetyltransferases. An azide-alkyne bioconjugation reaction, known as click chemistry, can then be used to readily tag acetylated proteins with fluorescent or biotinylated labels for subsequent analysis.2

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Technical Information
Formal Name S-4-pentynoate coenzyme A, trifluoroacetate salt
  • Click Tag™ 4-pentynoyl-CoA
Molecular Formula C26H40N7O17P3S • CF3COOH
Formula Weight 961.6
Purity ≥95%
Formulation A lyophilized powder
SMILES OC(C(F)(F)F)=O.NC1=NC=NC2=C1N=CN2[C@@]3([H])[C@@](O)([H])[C@@](OP(O)(O)=O)([H])[C@](COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSC(CCC#C)=O)=O)=O)(O)=O)(O)=O)([H])O3
InChI Code 1S/C26H40N7O17P3S.C2HF3O2/c1-4-5-6-17(35)54-10-9-28-16(34)7-8-29-24(38)21(37)26(2,3)12-47-53(44,45)50-52(42,43)46-11-15-20(49-51(39,40)41)19(36)25(48-15)33-14-32-18-22(27)30-13-31-23(18)33;3-2(4,5)1(6)7/h1,13-15,19-21,25,36-37H,5-12H2,2-3H3,(H,

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
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Additional Information

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References & Background Reading
Product Description References

1. Yang, Y., Ascano, J.M., and Hang, H.C. Bioorthogonal chemical reporters for monitoring protein acetylation. J Am Chem Soc 132 3640-3641 (2010).

2. Kolb, H.C., and Sharpless, K.B. The growing impact of click chemistry on drug discovery. Drug Discov Today 8(24) 1128-1137 (2003).

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