4-hydroxy Nonenal Glutathione (trifluoroacetate salt)
Item № 10627
Purity ≥95%
1 mg $53.00 $0.00
5 mg $239.00 $0.00
10 mg $424.00 $0.00
25 mg $928.00 $0.00

Pricing updated 2016-05-26. Prices are subject to change without notice.

Bulk Inquiry Form


Enter number, size, and select unit. Example: 2 x 500 mg

Please indicate any analytical testing requirements, special handling, packaging, or delivery requirements.

  • 4-HNE-GSH

4-hydroxy Nonenal Glutathione (HNE-GSH) is a major adduct formed by the reaction of 4-HNE with GSH.1,2,3,4 4-HNE-GSH levels in liver, plasma, or isolated cells can serve as biomarkers for oxidative stress.5 The trapping of 4-HNE by glutathione to give HNE-GSH prevents the formation of DNA adducts with 4-HNE.6,7 In human polymorphonuclear leukocytes, HNE-GSH is metabolized to 1,4-dihydroxynonene glutathione (DHN-GSH), 4-hydroxynonenoic acid glutathione (HNA-GSH), and 4-hydroxy nonenal mercapturic acid (HNE-MA).1

Download Product Insert Download Safety Data Sheet (SDS) Find Batch-Specific Documents

Related Products
View Related Product Categories
Technical Information
Formal Name L-γ-glutamyl-S-[(3)-tetrahydro-5-hydroxy-2-pentyl-3-furanyl]-L-cysteinyl-glycine
  • 4-HNE-GSH
Molecular Formula C19H33N3O8S • CF3COOH
Formula Weight 577.6
Purity ≥95%
Formulation A crystalline solid
InChI Code 1S/C19H33N3O8S.C2HF3O2/c1-2-3-4-5-13-14(8-17(26)30-13)31-10-12(18(27)21-9-16(24)25)22-15(23)7-6-11(20)19(28)29;3-2(4,5)1(6)7/h11-14,17,26H,2-10,20H2,1H3,(H,21,27)(H,22,23)(H,24,25)(H,28,29);(H,6,7)/t11?,12-,13?,14?,17?;/m1./s1

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere
Stability As supplied, 1 year from the QC date provided on the Certificate of Analysis, when stored properly
Product Downloads & Resources
Product Downloads

Download Product Insert

Download Safety Data Sheet (SDS)

Download free InChI Key generation software

Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

Get Batch-Specific Data and Documents by Batch Number

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, and GC-MS data.

Please enter your batch number(s) to access inserts
QC Sheets
Please enter your batch number(s) to access QC sheets
Certificates of Analysis
Please enter your batch number(s) to access Certificates of Analysis
GC-MS Data
Please enter your batch number(s) to access GC-MS data
References & Background Reading
Product Description References

1. Siems, W., Crifo, C., Capuozzo, E., et al. Metabolism of 4-hydroxy-2-nonenal in human polymorphonuclear leukocytes. Arch Biochem Biophys 503 248-252 (2010).

2. Laurent, A., Alary, J., Debrauwer, L., et al. Analysis in the rat of 4-hydroxynonenal metabolites excreted in bile: Evidence of enterohepatic circulation of these byproducts of lipid peroxidation. Chem Res Toxicol 12 887-894 (1999).

3. Siems, W., and Grune, T. Intracellular metabolism of 4-hydroxynonenal. Mol Aspects Med 24 167-175 (2003).

4. Alary, J., Fernandez, Y., Debrauwer, L., et al. Identification of intermediate pathways of 4-hydroxynonenal metabolism in the rat. Chem Res Toxicol 16 320-327 (2003).

5. Völkel, W., Alvarez-Sánchez, R., Weick, I., et al. Glutathione conjugates of 4-hydroxy-2(E)-nonenal as biomarkers of hepatic oxidative stress-induced lipid peroxidation in rats. Free Radic Biol Med 38 1526-1536 (2005).

6. King, A.O., Corley, E.G., Anderson, R.K., et al. An efficient synthesis of LTD4 antagonist L-699,392. J Org Chem 58 3731-3735 (1993).

7. Falletti, O., Cadet, J., Favier, A., et al. Trapping of 4-hydroxynonenal by glutathione efficiently prevents formation of DNA adducts in human cells. Free Radic Biol Med 42 1258-1269 (2007).

Technical Support
Contact Us
  • To streamline the process attach the appropriate questionnaire to your inquiry.

  • Toll Free Phone (USA and Canada Only): (888) 526-5351
  • Direct Phone: (734) 975-3888
Contract Research Services

We offer you the deep and diverse knowledge of more than 100 in-house scientists and the expertise that comes from more than three decades of designing and developing the tools to advance biomedical research.

Cayman is know as a partner to scientists worldwide, responding to your needs with services in:

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA