Item № 10956
CAS № 637-07-0
Purity ≥98%
500 mg $13.00 $0.00
1 g $25.00 $0.00
5 g $104.00 $0.00
10 g $182.00 $0.00

Pricing updated 2016-05-26. Prices are subject to change without notice.

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Peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription factor involved in the regulation of lipid homeostasis.1,2 Activation of PPARα results in expression of a variety of genes, particularly those involved in fatty acid β-oxidation, binding, and transport.3 Clofibrate is a PPARα agonist and a member of a class of hypolipidemic drugs that includes fenofibrate and benzafibrate, which have been used clinically to treat dyslipidemia and cardiovascular disease. In a transactivation assay, clofibrate exhibits EC50 values of 50 and 55 µM for mouse and human PPARα, respectively.4 It also binds to PPARγ, but with 10-fold less affinity and is inactive at PPARδ at concentrations up to 100 µM.4

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Technical Information
Formal Name 2-(4-chlorophenoxy)-2-methyl-propanoic acid, ethyl ester
CAS Number 637-07-0
Molecular Formula C12H15ClO3
Formula Weight 242.7
Purity ≥98%
Formulation A colorless liquid
λmax 226, 280 nm
SMILES CCOC(=O)C(C)(C)Oc1ccc(Cl)cc1
InChI Code 1S/C13H15ClO4/c1-4-17-12(16)11(15)13(2,3)18-10-7-5-9(14)6-8-10/h5-8H,4H2,1-3H3

WARNING - This product is not for human or veterinary use.

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Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
Stability As supplied, 1 year from the QC date provided on the Certificate of Analysis, when stored properly
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References & Background Reading
Product Description References

1. Latruffe, N., and Vamecq, J. Peroxisome proliferators and peroxisome proliferator activated receptors (PPARs) as regulators of lipid metabolism. Biochimie 79 81-94 (1997).

2. Lemberger, T., Desvergne, B., and Wahli, W. Peroxisome proliferator-activated receptors: A nuclear receptor signaling pathway in lipid physiology. Annu Rev Cell Dev Biol 12 335-363 (1996).

3. Mandard, S., Müller, M., and Kersten, S. Peroxisome proliferator-activated receptor .alpha. target genes. Cell Mol Life Sci 61 393-416 (2004).

4. Willson, T.M., Brown, P.J., Sternbach, D.D., et al. The PPARs: From orphan receptors to drug discovery. J Med Chem 43(4) 528-550 (2000).

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