EUK 124
Item № 12500
CAS № 186299-35-4
Purity ≥95%
5 mg $25.00 $0.00
10 mg $48.00 $0.00
50 mg $200.00 $0.00
100 mg $350.00 $0.00

Pricing updated 2016-05-26. Prices are subject to change without notice.

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EUK 8 and EUK 134 (Item No. 10006329) are synthetic catalytic scavengers of reactive oxygen species with superoxide dismutase (SOD) and catalase mimetic activity.1 EUK 124 is a structural analog of EUK 8 and EUK 134 with significantly reduced activity. EUK 124 and EUK 8 inhibit superoxide-mediated reduction of an electron acceptor (i.e., SOD mimetic activity), with IC50 values of 5 µM and 0.7 µM, respectively.2

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Technical Information
Formal Name chloro[[2,2’-[1,2-ethanediylbis[(nitrilo-κN)methylidyne]]bis[3,5-dimethoxyphenolato-κO]](2-)]-manganese
CAS Number 186299-35-4
Molecular Formula C20H22ClMnN2O6
Formula Weight 476.8
Purity ≥95%
Formulation A crystalline solid
SMILES [Cl-][Mn+3]123[N](CC[N]2=CC4=C(OC)C=C(OC)C=C4[O-]3)=CC5=C(OC)C=C(OC)C=C5[O-]1
InChI Code 1S/C20H24N2O6.ClH.Mn/c1-25-13-7-17(23)15(19(9-13)27-3)11-21-5-6-22-12-16-18(24)8-14(26-2)10-20(16)28-4;;/h7-12,23-24H,5-6H2,1-4H3;1H;/q;;+3/p-3/b21-11+,22-12+;;

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
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References & Background Reading
Product Description References

1. Baker, K., Marcus, C.B., Huffman, K., et al. Synthetic combined superoxide dismutase/catalase mimetics are protective as a delayed treatment in a rat stroke model: A key role for reactive oxygen species in ischemic brain injury. J Pharmacol Exp Ther 284(1) 215-221 (1998).

2. Doctrow, S.R., Huffman, K., Marcus, C.B., et al. Salen-manganese complexes as catalytic scavengers of hydrogen peroxide and cytoprotective agents: Structure-activity relationship studies. J Med Chem 45 4549-4558 (2002).

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