1a,1b-dihomo Prostaglandin E1
Item № 13050
CAS № 23452-98-4
Purity ≥98%
1 mg $51.00 $0.00
5 mg $230.00 $0.00
10 mg $408.00 $0.00

Pricing updated 2016-05-04. Prices are subject to change without notice.

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  • 1a,1b-dihomo PGE1

Prostaglandin E1 (PGE1) is not a major naturally occurring PG, but is widely administered clinically for several indications including peripheral occlusive vascular disease, erectile dysfunction, and in neonatal cardiology.1,2 COX metabolism of the unusual fatty acid 10,13,16-docosatrienoic acid yields 1a,1b-dihomo PGE1. This rare metabolite has been recovered from incubations of whole sheep seminal vesicles, but has not been reported in humans.3 In ex vivo preparations of rat aorta and rat PRP, 1a,1b-dihomo PGE1 was found to be much less active than PGE1 itself.4

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Technical Information
Formal Name 9-oxo-11α,15S-dihydroxy-1a,1b-dihomo-prost-13E-en-1-oic acid
CAS Number 23452-98-4
  • 1a,1b-dihomo PGE1
Molecular Formula C22H38O5
Formula Weight 382.5
Purity ≥98%
Formulation A solution in methyl acetate
InChI Code 1S/C22H38O5/c1-2-3-8-11-17(23)14-15-19-18(20(24)16-21(19)25)12-9-6-4-5-7-10-13-22(26)27/h14-15,17-19,21,23,25H,2-13,16H2,1H3,(H,26,27)/b15-14+/t17-,18+,19+,21+/m0/s1

WARNING - This product is not for human or veterinary use.

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Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability As supplied, 1 year from the QC date provided on the Certificate of Analysis, when stored properly
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References & Background Reading
Product Description References

1. Virag, R., Shoukry, K., Floresco, J., et al. Intracavernous self-injection of vasoactive drugs in the treatment of impotence: 8-Year experience with 615 cases. J Urol 145 287-293 (1991).

2. Hoshi, K. Approved indications of lipo-PGE1 in Japan. Adv Drug Deliv Rev 20 171-176 (1996).

3. Samel, N., and Maxey, K.M. Personal Communication. (2003).

4. Kloeze, J. Relationship between chemical structure and platelet-aggregation activity of prostaglandins. Biochim Biophys Acta 187 285-292 (1969).

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