Item № 13179
CAS № 1071000-98-0
Purity ≥98%
500 µg $36.00 $0.00
1 mg $68.00 $0.00
5 mg $288.00 $0.00
10 mg $504.00 $0.00

Pricing updated 2016-05-24. Prices are subject to change without notice.

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Phospholipase A2 (PLA2) catalyzes the hydrolysis of fatty acids at the sn-2 position of glycerophospholipids, yielding a free fatty acid and a lysophospholipid as products. There are three broad classes of PLA2, secretory (sPLA2), calcium-dependent cytosolic (cPLA2), and calcium-independent cytosolic (iPLA2), that have different functions. FKGK 11 is a selective inhibitor of iPLA2 that demonstrates an XI(50) value of 0.0073, where XI(50) equals the mole fraction of FKGK 11 in the total substrate interface required to inhibit iPLA2 by 50%.1 In comparison, mole fractions as high as 0.091 do not inhibit cPLA2 activity and cause only slight inhibition of sPLA2.1

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Technical Information
Formal Name 1,1,1,2,2-pentafluoro-7-phenyl-3-heptanone
CAS Number 1071000-98-0
Molecular Formula C13H13F5O
Formula Weight 280.2
Purity ≥98%
Formulation A solution in ethanol
InChI Code 1S/C13H13F5O/c14-12(15,13(16,17)18)11(19)9-5-4-8-10-6-2-1-3-7-10/h1-3,6-7H,4-5,8-9H2

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
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Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

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References & Background Reading
Product Description References

1. Baskakis, C., Magrioti, V., Cotton, N., et al. Synthesis of polyfluoro ketones for selective inhibition of human phospholipase A2 enzymes. J Med Chem 51 8027-8037 (2008).

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