Item № 13186
CAS № 674289-55-5
Purity ≥98%
5 mg $69.00 $0.00
10 mg $104.00 $0.00
25 mg $242.00 $0.00
50 mg $449.00 $0.00

Pricing updated 2016-05-05. Prices are subject to change without notice.

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(±)-Blebbistatin is a selective cell-permeable inhibitor of non-muscle myosin II ATPases.1,2 It rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC50 = 0.5-5.0 μM), while poorly inhibiting smooth muscle myosin (IC50 = 80 μM).3 Through these effects, blebbistatin blocks apoptosis-related bleb formation, directed cell migration and cytokinesis in vertebrate cells. Blebbistatin is inactivated by UV light,4 which may be particularly important in fluorescent cell imaging applications. Purified enantiomers of Blebbistatin are also available from Cayman ((−)-Blebbistatin - Item No. 13013; (+)-Blebbistatin - Item No. 13165).

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Technical Information
Formal Name 1,2,3,3a-tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-b]quinolin-4-one
CAS Number 674289-55-5
Molecular Formula C18H16N2O2
Formula Weight 292.3
Purity ≥98%
Formulation A crystalline solid
λmax 236, 270, 298, 417 nm
SMILES Cc1ccc2N=C3N(CCC3(O)C(=O)c2c1)c1ccccc1
InChI Code 1S/C18H16N2O2/c1-12-7-8-15-14(11-12)16(21)18(22)9-10-20(17(18)19-15)13-5-3-2-4-6-13/h2-8,11,22H,9-10H2,1H3

WARNING - This product is not for human or veterinary use.

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Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
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References & Background Reading
Product Description References

1. Straight, A.F., Cheung, A., Limouze, J., et al. Dissecting temporal and spatial control of cytokinesis with a myosin II inhibitor. Science 299 1743-1747 (2003).

2. Kovács, M., Tóth, J., Hetényi, C., et al. Mechanism of blebbistatin inhibition of myosin II. J Biol Chem 279(34) 35557-35563 (2004).

3. Limouze, J., Straight, A.F., Mitchison, T., et al. Specificity of blebbistatin, an inhibitor of myosin II. J Muscle Res Cell Motil 25 337-341 (2004).

4. Kolega, J. Phototoxicity and photoinactivation of blebbistatin in UV and visible light. Biochem Biophys Res Commun 320 1020-1025 (2004).

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