Bisindolylmaleimide I
Item № 13298
CAS № 133052-90-1
Purity ≥95%
5 mg $69.00 $0.00
10 mg $131.00 $0.00
25 mg $311.00 $0.00
50 mg $552.00 $0.00

Pricing updated 2016-04-29. Prices are subject to change without notice.

Bulk Inquiry Form


Enter number, size, and select unit. Example: 2 x 500 mg

Please indicate any analytical testing requirements, special handling, packaging, or delivery requirements.

  • BIM I
  • GF 109203X
  • Gö 6850

Bisindolylmaleimide I (BIM I) is a highly selective, cell-permeable, and reversible protein kinase C (PKC) inhibitor (Ki = 14 nM) that is structurally similar to the poorly selective PKC inhibitor staurosporine.1 It acts as a competitive inhibitor for the ATP binding site of PKC and shows high selectivity for PKCα-, β1-, β2-, γ-, δ-, and ε-isozymes.1 BIM I directly inhibits GSK3 in primary adipocyte lysates (IC50 = 360 nM) and in GSK3β immunoprecipitates derived from rat epididymal adipocytes (IC50 = 170 nM).2 This compound also competitively antagonizes the 5-HT3 receptor with a Ki value of 61 nM.3

Download Product Insert Download Safety Data Sheet (SDS)

Related Products
View Related Product Categories
Technical Information
Formal Name 3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
CAS Number 133052-90-1
  • BIM I
  • GF 109203X
  • Gö 6850
Molecular Formula C25H24N4O2
Formula Weight 412.5
Purity ≥95%
Formulation A crystalline solid
SMILES CN(C)CCCn1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc12
InChI Code 1S/C25H24N4O2/c1-28(2)12-7-13-29-15-19(17-9-4-6-11-21(17)29)23-22(24(30)27-25(23)31)18-14-26-20-10-5-3-8-16(18)20/h3-6,8-11,14-15,26H,7,12-13H2,1-2H3,(H,27,30,31)

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Product Downloads & Resources
Product Downloads

Download Product Insert

Download Safety Data Sheet (SDS)

Download free InChI Key generation software

Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

Get Batch-Specific Data and Documents by Batch Number

Separate multiple batch numbers with commas

QC Sheets
Certificates of Analysis
References & Background Reading
Product Description References

1. Toullec, D., Pianetti, P., Coste, H., et al. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J Biol Chem 266(24) 15771-15781 (1991).

2. Hers, I., Tavaré, J.M., and Denton, R.M. The protein kinase C inhibitors bisindolylmaleimide I (GF 109203x) and IX (Ro 31-8220) are potent inhibitors of glycogen synthase kinase-3 activity. FEBS Lett 460 433-436 (1999).

3. Coultrap, S.J., Sun, H., Tenner, T.E., et al. Competitive antagonism of the mouse 5-hydroxytryptamine receptor by bisindolylmaleimide I, a “selective” protein kinase C inhibitor. J Pharmacol Exp Ther 290(1) 76-82 (1999).

Technical Support
Contact Us
  • To streamline the process attach the appropriate questionnaire to your inquiry.

  • Toll Free Phone (USA and Canada Only): (888) 526-5351
  • Direct Phone: (734) 975-3888
Contract Research Services

We offer you the deep and diverse knowledge of more than 100 in-house scientists and the expertise that comes from more than three decades of designing and developing the tools to advance biomedical research.

Cayman is know as a partner to scientists worldwide, responding to your needs with services in:

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA