Gö 6983
Item № 13311
CAS № 133053-19-7
Purity ≥98%
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1 mg $35.00 $0.00
5 mg $120.00 $0.00
10 mg $180.00 $0.00

Pricing updated 2016-05-25. Prices are subject to change without notice.

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Description

Gö 6983 inhibits several isoforms of protein kinase C (PKC; IC50 = 7, 7, 6, 10, 60, and 20,000 nM for PKCα, PKCβ, PKCγ, PKCδ, PKCζ, and PKCμ, respectively).1 It provides cardioprotective effects in myocardial ischemia/reperfusion by attenuating contractile dysfunction.2,3

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Technical Information
Formal Name 3-[1-[3-(dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
CAS Number 133053-19-7
Molecular Formula C26H26N4O3
Formula Weight 442.5
Purity ≥98%
Formulation A crystalline solid
SMILES COc1ccc2n(CCCN(C)C)cc(C3=C(C(=O)NC3=O)c3c[nH]c4ccccc34)c2c1
InChI Code 1S/C26H26N4O3/c1-29(2)11-6-12-30-15-20(18-13-16(33-3)9-10-22(18)30)24-23(25(31)28-26(24)32)19-14-27-21-8-5-4-7-17(19)21/h4-5,7-10,13-15,27H,6,11-12H2,1-3H3,(H,28,31,32)
InChI Key LLJJDLHGZUOMQP-UHFFFAOYSA-N

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
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References & Background Reading
Product Description References

1. Gschwendt, M., Dieterich, S., Rennecke, J., et al. Inhibition of protein kinase C .mu. by various inhibitors. Differentiation from protein kinase c isoenzymes. FEBS Lett 392 77-80 (1996).

2. Peterman, E.E., Taormina, P.I., Harvey, M., et al. Gö 6983 exerts cardioprotective effects in myocardial ischemia/reperfusion. J Cardiovasc Pharmacol 43 645-656 (2004).

3. Young, L.H., Balin, B.J., and Weis, M.T. Gö 6983: A fast acting protein kinase C inhibitor that attenuates myocardial ischemia/reperfusion injury. Cardiovasc Drug Rev 23(3) 255-272 (2005).

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