Bisindolylmaleimide IX (mesylate)
Item № 13334
CAS № 138489-18-6
Purity ≥98%
1 mg $35.00 $0.00
5 mg $135.00 $0.00
10 mg $199.00 $0.00

Pricing updated 2016-05-06. Prices are subject to change without notice.

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  • BIM IX
  • Ro 31-8220

Bisindolylmaleimide IX (BIM IX) is a potent, cell-permeable inhibitor of protein kinase C (PKC) isoforms (IC50 = 5, 24, 14, 27, and 24 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, and PKC-ε, respectively).1 It is a poor inhibitor of protein kinase A (PKA, IC50 = 0.9 μM) and calcium/calmodulin kinase II (IC50 = 17 μM). BIM IX also inhibits glycogen synthase kinase 3 (IC50 = 6.8 nM).2

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Technical Information
Formal Name 3-[3-[2,5-dihydro-4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-1H-pyrrol-3-yl]-1H-indol-1-yl]propyl ester-methanesulfonate, carbamimidothioic acid
CAS Number 138489-18-6
  • BIM IX
  • Ro 31-8220
Molecular Formula C25H23N5O2S • CH3SO3H
Formula Weight 553.7
Purity ≥98%
Formulation A crystalline solid
SMILES O=C(N1[H])C(C2=CN(C)C3=C2C=CC=C3)=C(C4=CN(CCCS/C(N)=N\[H])C5=C4C=CC=C5)C1=O.CS(=O)(O)=O
InChI Code 1S/C25H23N5O2S.CH4O3S/c1-29-13-17(15-7-2-4-9-19(15)29)21-22(24(32)28-23(21)31)18-14-30(11-6-12-33-25(26)27)20-10-5-3-8-16(18)20;1-5(2,3)4/h2-5,7-10,13-14H,6,11-12H2,1H3,(H3,26,27)(H,28,31,32);1H3,(H,2,3,4)

WARNING - This product is not for human or veterinary use.

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Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
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References & Background Reading
Product Description References

1. Wilkinson, S.E., Parker, P.J., and Nixon, J.S. Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C. Biochem J 294 335-337 (1993).

2. Hers, I., Tavaré, J.M., and Denton, R.M. The protein kinase C inhibitors bisindolylmaleimide I (GF 109203x) and IX (Ro 31-8220) are potent inhibitors of glycogen synthase kinase-3 activity. FEBS Lett 460 433-436 (1999).

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