GYY 4137
Item № 13345
CAS № 106740-09-4
Purity ≥95%
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL $0.00
10 mg $47.00 $0.00
25 mg $112.00 $0.00
50 mg $212.00 $0.00
100 mg $376.00 $0.00

Pricing updated 2016-05-26. Prices are subject to change without notice.

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Description

Hydrogen sulfide (H2S) is a gaseous mediator which, like nitric oxide (NO), has numerous profound actions in mammalian physiology. GYY 4137 is a water-soluble, slow-releasing hydrogen sulfide (H2S) donor.1 When given intravenously, it demonstrates vasodilator and anti-hypertensive activity in rats, in either the acute (L-NAME-induced) or chronic (spontaneously hypertensive) hypertension models.1 Intravenous GYY 4137 also protects against endotoxic shock in rats, inhibiting tumor necrosis factor-α, interleukin (IL)-1β, and IL-6 production and reducing NF-κB activation, iNOS and cyclooxygenase-2 expression, and NO and prostaglandin E2 generation.2

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Technical Information
Formal Name (p-methoxyphenyl)morpholino-phosphinodithioic acid
CAS Number 106740-09-4
Molecular Formula C11H16NO2PS2 • C4H10NO
Formula Weight 377.5
Purity ≥95%
Formulation A crystalline solid
SMILES COc1ccc(cc1)P(=S)([S-])N1CCOCC1.C1COCC[NH2+]1
InChI Code 1S/C11H16NO2PS2.C4H9NO/c1-13-10-2-4-11(5-3-10)15(16,17)12-6-8-14-9-7-12;1-3-6-4-2-5-1/h2-5H,6-9H2,1H3,(H,16,17);5H,1-4H2
InChI Key YZMHNNLDUWRZFW-UHFFFAOYSA-N

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
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References & Background Reading
Product Description References

1. Li, L., Whiteman, M., Guan, Y.Y., et al. Characterization of a novel, water-soluble hydrogen sulfide releasing molecule (GYY4137): New insights into the biology of hydrogen sulfide. Circulation 117 2351-2360 (2008).

2. Li, L., Salto-Tellez, M., Tan, C., et al. GYY4137, a novel hydrogen sulfide-releasing molecule, protects against endotoxic shock in the rat. Free Radic Biol Med 47 103-113 (2009).

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