Bicyclo Prostaglandin E2
Item № 14530
CAS № 74158-09-1
Purity ≥98%
1 mg $59.00 $0.00
5 mg $266.00 $0.00
10 mg $472.00 $0.00

Pricing updated 2016-05-03. Prices are subject to change without notice.

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  • Bicyclo PGE2

Bicyclo prostaglandin E2 (bicyclo PGE2) is a stable breakdown product of PGE2 (Item No. 14010) and 13,14-dihydro-15-keto PGE2 (Item No. 14650). Bicyclo PGE2 is a stable, base-catalyzed transformation product of 13,14-dihydro-15-keto PGE2. 13,14-dihydro-15-keto PGE2 itself is a metabolite of PGE2 found in human plasma at a median level of 20-25 pg/ml.1,2 Due to the inherent instability of 13,14-dihydro-15-keto PGE2, it is advisable to quantify it as bicyclo PGE2 to estimate PGE2 biosynthesis or metabolism in vivo.3,4

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Technical Information
Formal Name 11-deoxy-13,14-dihydro-15-keto-11β,16.xi.-cycloprostaglandin E2
CAS Number 74158-09-1
  • Bicyclo PGE2
Molecular Formula C20H30O4
Formula Weight 334.5
Purity ≥98%
Formulation A solution in methyl acetate
InChI Code 1S/C20H30O4/c1-2-3-8-16-17-13-19(22)15(14(17)11-12-18(16)21)9-6-4-5-7-10-20(23)24/h4,6,14-17H,2-3,5,7-13H2,1H3,(H,23,24)/b6-4-/t14-,15-,16?,17+/m1/s1

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
Stability As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
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References & Background Reading
Product Description References

1. Hamberg, M., and Samuelsson, B. On the metabolism of prostaglandins E1 and E2 in man. J Biol Chem 246 6713-6721 (1971).

2. Leonhardt, A., Krauss, M., Gieler, U., et al. In vivo formation of prostaglandin E1 and prostaglandin E2 in atopic dermatitis. Br J Dermatol 136 337-340 (1997).

3. Murphy, R.C., and Fitzgerald, G.A. Current approaches to estimation of eicosanoid formation in vivo. Adv Prostaglandin Thromboxane Leukot Res 22 341-348 (1994).

4. Granström, E., Hamberg, M., Hansson, G., et al. Chemical instability of 15-keto-13,14-dihydro-PGE2: The reason for low assay reliability. Prostaglandins 19 933-945 (1980).

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