Fentanyl (hydrochloride) RM
Item № 14719
CAS № 1443-54-5
Purity ≥98%
Formulation A neat solid
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Description

Fentanyl is an agonist of the μ-opioid receptor (Ki = 0.39 nM) that less effectively binds the κ-opioid receptor (Ki = 255 nM) and does not act at the δ-opioid receptor.1 It is used for anesthesia and chronic pain management.2,3 Fentanyl, compared to morphine, is both more effective at reducing pain (ED50 values are 0.0061 vs. 0.33 mg/kg, respectively) and more lethal (LD50 values are 62 vs. 470 mg/kg, respectively).4 Fentanyl is abused recreationally and is regulated as a Schedule II controlled substance in the United States.5

Cayman Chemical products containing Reference Material (RM) in the name are highly qualified materials manufactured and tested to meet ISO/IEC 17025:2005 and ISO Guide 34:2009 international guidelines for reference materials. These materials are tested using validated analytical methods on qualified instrumentation to ensure traceability to SI units of measure.

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RMs and CRMs produced to accreditation standards: ISO/IEC 17025:2005 · ISO Guide 34:2009
RESTRICTED PRODUCT This product is a controlled substance and special processing is required before shipping.
WARNING - This product is for laboratory research only. Not for administration to humans. Not for human or veterinary diagnostic or therapeutic use.
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Technical Information
Formal Name N-phenyl-N-[1-(2-phenylethyl)-4-piperidinyl]-propanamide, monohydrochloride
CAS Number 1443-54-5
Molecular Formula C22H28N2O • HCl
Formula Weight 372.9
Purity ≥98%
Formulation A neat solid
SMILES O=C(N(C1=CC=CC=C1)C2CCN(CCC3=CC=CC=C3)CC2)CC.Cl
InChI Code 1S/C22H28N2O.ClH/c1-2-22(25)24(20-11-7-4-8-12-20)21-14-17-23(18-15-21)16-13-19-9-5-3-6-10-19;/h3-12,21H,2,13-18H2,1H3;1H
InChI Key LHCBOXPPRUIAQT-UHFFFAOYSA-N

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability See Certificate of Analysis
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References & Background Reading
Product Description References

1. Raynor, K., Kong, H., Chen, Y., et al. Pharmacological characterization of the cloned .kappa.-, .delta.-, and .mu.-opioid receptors. Mol Pharmacol 45(2) 330-334 (1994).

2. Bovill, J.G., Sebel, P.S., and Stanley, T.H. Opioid analgesics in anesthesia: With special reference to their use in cardiovascular anesthesia. Anesthesiology 61 731-755 (1984).

3. Garg, A., Solas, D.W., Takahashi, L.H., et al. Forced degradation of fentanyl: Identification and analysis of impurities and degradants. J Pharm Biomed Anal 53(3) 325-334 (2010).

4. Higashikawa, Y., and Suzuki, S. Studies on 1-(2-phenethyl)-4-(N-propionylanilino)piperidine (fentanyl) and its related compounds. VI. Structure-analgesic activity relationship for fentanyl, methyl-substituted fentanyls and other analogues. Forensic Toxicol 26(1) 1-5 (2008).

5. Lendoiro, E., Quintela Ó, de Castro, A., et al. Target screening and confirmation of 35 licit and illicit drugs and metabolites in hair by LC–MSMS. Forensic Sci Int 217(1-3) 207-215 (2012).

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