15-keto Prostaglandin E2
Item № 14720
CAS № 26441-05-4
Purity ≥99%
500 µg $52.00 $0.00
1 mg $99.00 $0.00
5 mg $416.00 $0.00
10 mg $728.00 $0.00

Pricing updated 2016-05-24. Prices are subject to change without notice.

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  • 15-keto PGE2

15-keto Prostaglandin E2 (15-keto PGE2) is a metabolite of PGE2 formed by 15-hydroxy PGDH.1,2 In vivo, 15-keto PGE2 is essentially inactive. It has an attenuated affinity for the EP4 and EP2 receptors compared to PGE2 (Ki = 2,600-15,000 nM for the inhibition of PGE2 binding compared to a Kd = 1 nM for PGE2).3

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Technical Information
Formal Name 9,15-dioxo-11α-hydroxy-prosta-5Z,13E-dien-1-oic acid
CAS Number 26441-05-4
  • 15-keto PGE2
Molecular Formula C20H30O5
Formula Weight 350.5
Purity ≥99%
Formulation A crystalline solid
λmax 229 nm
InChI Code 1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,16-17,19,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t16-,17-,19-/m1/s1

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
Stability As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
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Additional Information

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References & Background Reading
Product Description References

1. Hamberg, M., and Samuelsson, B. On the metabolism of prostaglandins E1 and E2 in man. J Biol Chem 246 6713-6721 (1971).

2. Mak, O.T., Liu, Y., and Tai, H. Purification and characterization of NAD+-dependent 15-hydroxyprostaglandin dehydrogenase from porcine kidney. Biochim Biophys Acta 1035 190-196 (1990).

3. Nishigaki, N., Negishi, M., and Ichikawa, A. Two Gs-coupled prostaglandin E receptor subtypes, EP2 and EP4, differ in desensitization and sensitivity to the metabolic inactivation of the agonist. Mol Pharmacol 50 1031-1037 (1996).

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