20-ethyl Prostaglandin E2
Item № 14940
CAS № 37492-24-3
Purity ≥97%
1 mg $51.00 $0.00
5 mg $230.00 $0.00
10 mg $408.00 $0.00

Pricing updated 2016-05-06. Prices are subject to change without notice.

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  • 20-ethyl PGE2

20-ethyl Prostaglandin E2 (20-ethyl PGE2) is an analog of PGE2 in which the ω-chain has been extended by the addition of two methylene carbon atoms. The only well studied prostaglandin analog with this structural feature is unoprostone, an F-series prostaglandin that is clinically approved as a glaucoma medication.1 Unoprostone also contains lower side chain modifications (13,14-dihydro-15-keto) which severely limit its affinity for FP receptors, contributing to its lack of potency as a medication. 20-ethyl PGE2 retains the natural 15(S) allylic hydroxyl in the lower side chain, which may improve its potency relative to unoprostone. However, ligand binding assays of this analog with respect to EP or other prostanoid receptors have not been published. E-type prostaglandins have been widely reported to have inflammatory,2 cytoprotective,3 and a variety of other effects.4

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Technical Information
Formal Name 9-oxo-11α,15S-dihydroxy-20a,20b-dihomoprosta-5Z,13E-dien-1-oic acid
CAS Number 37492-24-3
  • 20-ethyl PGE2
Molecular Formula C22H36O5
Formula Weight 380.5
Purity ≥97%
Formulation A solution in methyl acetate
InChI Code 1S/C22H36O5/c1-2-3-4-5-8-11-17(23)14-15-19-18(20(24)16-21(19)25)12-9-6-7-10-13-22(26)27/h6,9,14-15,17-19,21,23,25H,2-5,7-8,10-13,16H2,1H3,(H,26,27)/b9-6-,15-14+/t17-,18+,19+,21+/m0/s1

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
Stability As supplied, 1 year from the QC date provided on the Certificate of Analysis, when stored properly
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References & Background Reading
Product Description References

1. Haria, M., and Spencer, C.M. Unoprostone (isopropyl unoprostone). Drugs Aging 9 213-218 (1996).

2. Matsumoto, H., Naraba, H., Murakami, M., et al. Concordant induction of prostaglandin E2 synthase with cyclooxygenase-2 leads to preferred production of prostaglandin E2 over thromboxane and prostaglandin D2 in lipopolysaccharide-stimulated rat peritoneal macrophages. Biochem Biophys Res Commun 230 110-114 (1997).

3. Karim, S.M.M., Carter, D.C., Bhana, D., et al. Effect of orally administered prostaglandin E2 and its 15-methyl analogues on gastric secretion. Br Med J 1 143-146 (1973).

4. Jackson, G.M., Sharp, H.T., and Varner, M.W. Cervical ripening before induction of labor: A randomized trial of prostaglandin E2 gel versus low-dose oxytocin. Am J Obstet Gynecol 171 1092-1096 (1994).

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