Item № 15590
CAS № 217082-60-5
1 mg $109.00 $0.00

Pricing updated 2016-05-05. Prices are subject to change without notice.

Bulk Inquiry Form


Enter number, size, and select unit. Example: 2 x 500 mg

Please indicate any analytical testing requirements, special handling, packaging, or delivery requirements.

  • (pGlu1)Apelin-13
  • Pyr-Apelin-13
  • (Pyr1)Apelin-13

The apelin gene encodes a pre-proprotein that is processed to generate bioactive peptides consisting of 36, 17, or 13 amino acids: apelin-36 (Item No. 13524), apelin-17, and apelin-13 (Item No. 13523), respectively. Apelin-13 is an endogenous ligand of the APJ receptor, activating this G protein-coupled receptor with an EC50 value of 0.37 nM.1,2 (Glp1)-Apelin-13 is a pyroglutamylated form of apelin-13, in that the N-terminal glutamine residue is cyclized to pyroglutamic acid. Like apelin-13, this compound is a potent APJ receptor agonist (EC50 = 0.30 nM).1 (Glp1)-Apelin-13 is the major apelin isoform in the plasma of healthy human subjects.3 It can have vasoconstrictor and antipyretic effects in vitro and in vivo.4,5,6

Download Product Insert Download Safety Data Sheet (SDS)

Related Products
View Related Product Categories
Technical Information
CAS Number 217082-60-5
  • (pGlu1)Apelin-13
  • Pyr-Apelin-13
  • (Pyr1)Apelin-13
Formula Weight 1533.8
Formulation A white to off-white solid
SMILES O=C(N(CCC1)[C@@H]1C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@H](C(N[C@@H](CCCCN)C(NCC(N(CCC2)[C@@H]2C(N[C@@H](CCSC)C(N(CCC3)[C@@H]3C(N[C@H](C(O)=O)CC4=CC=CC=C4)=O)=O)=O)=O)=O)=O)CC5=CNC=N5)=O)=O)=O)=O)[C@H](CCCNC(N)=N)NC([C@@H](N6)CCC6=
InChI Code 1S/C69H108N22O16S/c1-39(2)32-47(85-57(96)43(17-9-26-76-68(71)72)82-63(102)52-20-12-29-90(52)65(104)45(18-10-27-77-69(73)74)83-58(97)44-22-23-54(93)80-44)59(98)88-50(37-92)61(100)86-48(34-41-35-75-38-79-41)60(99)81-42(16-7-8-25-70)56(95)78-36-55

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability As supplied, 1 year from the QC date provided on the Certificate of Analysis, when stored properly
Product Downloads & Resources
Product Downloads

Download Product Insert

Download Safety Data Sheet (SDS)

Download free InChI Key generation software

Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

Get Batch-Specific Data and Documents by Batch Number

Separate multiple batch numbers with commas

QC Sheets
Certificates of Analysis
References & Background Reading
Product Description References

1. Tatemoto, K., Hosoya, M., Habata, Y., et al. Isolation and characterizaton of a novel endogenous peptide ligand for the human APJ receptor. Biochem Biophys Res Commun 251 471-476 (1998).

2. Lee, D.K., Cheng, R., Nguyen, T., et al. Characterization of apelin, the ligand for the APJ receptor. J Neurochem 74 34-41 (2000).

3. Zhen, E.Y., Higgs, R.E., and Gutierrez, J.A. Pyroglutamyl apelin-13 identified as the major apelin isoform in human plasma. Anal Biochem 442(1) 1-9 (2013).

4. Katugampola, S.D., Maguire, J.J., Matthewson, S.R., et al. [125I]-(Pyr1)Apelin-13 is a novel radioligand for localizing the APJ orphan receptor in human and rat tissues with evidence for a vasoconstrictor role in man. Br J Pharmacol 132(6) 1255-1260 (2001).

5. Kagiyama, S., Fukuhara, M., Matsumura, K., et al. Central and peripheral cardiovascular actions of apelin in conscious rats. Regul Pept 125(1-3) 55-59 (2005).

6. Hatzelmann, T., Harden, L.M., Roth, J., et al. Antipyretic effect of central [Pyr1]apelin13 on LPS-induced fever in the rat. Regul Pept 184 6-13 (2013).

Technical Support
Contact Us
  • To streamline the process attach the appropriate questionnaire to your inquiry.

  • Toll Free Phone (USA and Canada Only): (888) 526-5351
  • Direct Phone: (734) 975-3888
Contract Research Services

We offer you the deep and diverse knowledge of more than 100 in-house scientists and the expertise that comes from more than three decades of designing and developing the tools to advance biomedical research.

Cayman is know as a partner to scientists worldwide, responding to your needs with services in:

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA