17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F
Item № 15895
CAS № 1027401-98-4
Purity ≥98%
1 mg $51.00 $0.00
5 mg $230.00 $0.00
10 mg $408.00 $0.00

Pricing updated 2016-05-24. Prices are subject to change without notice.

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  • 17-TFM-PGF

A number of 17-aryl trinor and 16-aryloxy tetranor prostaglandin F derivatives have been approved for the treatment of glaucoma.1,2,3 These “ring” prostaglandin (PG) analogs have improved efficacy over the PGs with an n-alkyl lower side chain. Of these, the ones wherein the 13,14-double bond has been hydrogenated retain relatively good potency, but show a significantly reduced incidence of local irritant side effects.4 17-trifluoromethylphenyl-13,14-dihydro trinor PGF (17-TFM-PGF) is a typical “ring” analog reminiscent of the trifluoromethyl-phenoxy ring of Travoprost. The a chain of 17-TFM-PGF is saturated, making this compound a formal member of the one-series PGs. Recent work has shown that in the “ring” series of analogs, this modification has little impact on FP receptor binding.5 As an ocular hypotensive agent, it is expected that 17-TFM-PGF would act very much like the free acid of latanoprost.

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Technical Information
Formal Name 9α,11α,15S-trihydroxy-17-trifluoromethylphenyl-18,19,20-trinor-prostan-1-oic acid
CAS Number 1027401-98-4
  • 17-TFM-PGF
Molecular Formula C24H35F3O5
Formula Weight 460.5
Purity ≥98%
Formulation A solution in methyl acetate
SMILES O[C@@H]1[C@H](CCCCCCC(O)=O)[C@@H](CC[C@@H](O)CCC2=CC(C(F)(F)F)=CC=C2)[C@H](O)C1
InChI Code 1S/C24H35F3O5/c25-24(26,27)17-7-5-6-16(14-17)10-11-18(28)12-13-20-19(21(29)15-22(20)30)8-3-1-2-4-9-23(31)32/h5-7,14,18-22,28-30H,1-4,8-13,15H2,(H,31,32)/t18-,19+,20+,21-,22+/m0/s1

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability As supplied, 1 year from the QC date provided on the Certificate of Analysis, when stored properly
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References & Background Reading
Product Description References

1. Woodward, D.F., Krauss, A.H., Chen, J., et al. The pharmacology of Bimatoprost (Lumigan™). Surv Ophthalmol 45 S337-S345 (2001).

2. Stjernschantz, J.W. From PGF2.alpha.-isopropyl ester to latanoprost: A review of the development of xalatan. The proper lecture. Invest Ophthamol Vis Sci 42(6) 1134-1145 (2001).

3. Sorbera, L.A., and Castañer, J. Travoprost. Drugs Future 25 41-45 (2000).

4. Resul, B., Stjernschantz, J., No, K., et al. Phenyl-substituted prostaglandins: Potent and selective antiglaucoma agents. J Med Chem 36 243-248 (1993).

5. deLong, M.A., Amburgey, J., Taylor, C., et al. Synthesis and in vitro evaluation of human FP-receptor selective prostaglandin analogues. Bioorg Med Chem Lett 10 1519-1522 (2000).

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