Prostaglandin F methyl ester
Item № 16011
CAS № 33854-16-9
Purity ≥98%
500 µg $25.00 $0.00
1 mg $48.00 $0.00
5 mg $200.00 $0.00
10 mg $350.00 $0.00

Pricing updated 2016-05-02. Prices are subject to change without notice.

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  • PGF methyl ester

Prostaglandin F methyl ester (PGF methyl ester) is an analog of PGF in which the C-1 carboxyl group has been esterified as the methyl ester. PGF methyl ester was one of the first PG esters shown to have ocular hypotensive activity.1 This compound continues to be a standard by which other ocular hypotensive PG prodrugs are evaluated. The methyl ester is about 4-5 times more potent than the free acid, PGF. This difference is attributed to improved corneal penetration, and a depot effect of prolonged retention of the ester form of the compound in ocular tissue. A 2.5 µg dose of PGF-OMe applied to the eyes of cats results in a 6-8 mm Hg reduction in IOP.1

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Technical Information
Formal Name 9α,11α,15S-trihydroxy-prosta-5Z,13E-dien-1-oic acid, methyl ester
CAS Number 33854-16-9
  • PGF methyl ester
Molecular Formula C21H36O5
Formula Weight 368.5
Purity ≥98%
Formulation A solution in methyl acetate
InChI Code 1S/C21H36O5/c1-3-4-7-10-16(22)13-14-18-17(19(23)15-20(18)24)11-8-5-6-9-12-21(25)26-2/h5,8,13-14,16-20,22-24H,3-4,6-7,9-12,15H2,1-2H3/b8-5-,14-13+/t16-,17+,18+,19-,20+/m0/s1

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability As supplied, 1 year from the QC date provided on the Certificate of Analysis, when stored properly
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References & Background Reading
Product Description References

1. Bito, L.Z. Comparison of the ocular hypotensive efficacy of eicosanoids and related compounds. Exp Eye Res 38 181-184 (1984).

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