Prostaglandin F diethyl amide
Item № 16023
Purity ≥98%
1 mg $42.00 $0.00
5 mg $189.00 $0.00
10 mg $336.00 $0.00

Pricing updated 2016-04-29. Prices are subject to change without notice.

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  • Dinoprost diethyl amide
  • PGF diethyl amide
  • PGF-NEt2

Prostaglandin F diethyl amide (PGF-NEt2) is an analog of PGF (Item No. 16010) in which the C-1 carboxyl group has been modified to an N-diethyl amide. PG esters have been shown to have ocular hypotensive activity.1 PG N-ethyl amides were recently introduced as alternative PG hypotensive prodrugs.2 Studies in our laboratories have shown that bovine and human corneal tissue converts the N-ethyl amides of various PGs to the free acids with a conversion efficiency of about 4 µg/g corneal tissue/hr.3 However, we find that dialkyl amides such as PGF-NEt2 are inert to corneal amidase activity, and are not converted in any detectable amount to the corresponding free acids. These compounds may therefore be useful tools in elucidating the claim that PG amides have intrinsic intraocular hypotensive activity.

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Technical Information
Formal Name N,N-diethyl-9α,11α,15S-trihydroxy-prosta-5Z,13E-dien-1-amide
  • Dinoprost diethyl amide
  • PGF diethyl amide
  • PGF-NEt2
Molecular Formula C24H43NO4
Formula Weight 409.6
Purity ≥98%
Formulation A solution in methyl acetate
InChI Code 1S/C24H43NO4/c1-4-7-10-13-19(26)16-17-21-20(22(27)18-23(21)28)14-11-8-9-12-15-24(29)25(5-2)6-3/h8,11,16-17,19-23,26-28H,4-7,9-10,12-15,18H2,1-3H3/b11-8-,17-16+/t19-,20+,21+,22-,23+/m0/s1

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
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Additional Information

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References & Background Reading
Product Description References

1. Bito, L.Z. Comparison of the ocular hypotensive efficacy of eicosanoids and related compounds. Exp Eye Res 38 181-184 (1984).

2. Woodward, D.F., Krauss, A.H., Chen, J., et al. The pharmacology of Bimatoprost (Lumigan™). Surv Ophthalmol 45 S337-S345 (2001).

3. Maxey, K.M., Johnson, J., Camras, C.B., et al. The hydrolysis of bimatoprost in corneal tissue generates a potent prostanoid FP receptor agonist. Surv Ophthalmol 47(4) 34-40 (2002).

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