Prostaglandin F isopropyl ester
Item № 16030
CAS № 53764-90-2
Purity ≥98%
1 mg $57.00 $0.00
5 mg $257.00 $0.00
10 mg $456.00 $0.00

Pricing updated 2016-05-02. Prices are subject to change without notice.

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  • Dinoprost isopropyl ester
  • PGF isopropyl ester

PGF isopropyl ester is an ester prodrug of PGF with enhanced lipid solubility. Due to better membrane penetration, PGF isopropyl ester is more suitable than PGF or PGF tromethamine salt for topical application in studies on intraocular pressure. The ester functionality is readily hydrolyzed in vivo to release the active compound PGF. When administered topically to the eyes of cynomolgus monkeys, a 5 µg dose reduces intraocular pressure by 68% after the fourth day of treatment.1

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Technical Information
Formal Name 9α,11α,15S-trihydroxy-prosta-5Z,13E-dien-1-oic acid, isopropyl ester
CAS Number 53764-90-2
  • Dinoprost isopropyl ester
  • PGF isopropyl ester
Molecular Formula C23H40O5
Formula Weight 396.6
Purity ≥98%
Formulation A solution in methyl acetate
SMILES O[C@@H]1[C@H](C/C=C\CCCC(OC(C)C)=O)[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C1
InChI Code 1S/C23H40O5/c1-4-5-8-11-18(24)14-15-20-19(21(25)16-22(20)26)12-9-6-7-10-13-23(27)28-17(2)3/h6,9,14-15,17-22,24-26H,4-5,7-8,10-13,16H2,1-3H3/b9-6-,15-14+/t18-,19+,20+,21-,22+/m0/s1

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
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Additional Information

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References & Background Reading
Product Description References

1. Crawford, K.S., and Kaufman, P.L. Dose-related effects of prostaglandin F2.alpha. isopropyl ester on intraocular pressure, refraction, and pupil diameter in monkeys. Invest Ophthamol Vis Sci 32 510-519 (1991).

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