2,3-dinor-8-iso Prostaglandin F
Item № 16290
CAS № 221664-05-7
Purity ≥98%
25 µg $61.00 $0.00
50 µg $116.00 $0.00
100 µg $220.00 $0.00
1 mg $1,708.00 $0.00

Pricing updated 2016-05-25. Prices are subject to change without notice.

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  • 2,3-dinor-iPF-III
  • 2,3-dinor-8-iso PGF

8-iso Prostaglandin F (8-iso PGF; 8-isoprostane) is a prostaglandin-like product of non-specific lipid peroxidation.1 2,3-dinor-8-iso PGF is a metabolite of 8-iso PGF in humans and rats.2 In these species, exogenously infused 8-iso PGF is converted to 2,3-dinor-8-iso PGF and (2,3-dinor-8-iso PGF.2,3 Rat hepatocytes further metabolize 8-iso PGF to another β-oxidation product, 2,3,4,5-tetranor-8-iso PGF.2 2,3-dinor-8-iso PGF is present in normal human urine at concentrations of 200-300 pg/ml.2 Its concentration is increased in conditions of oxidative injury (for example, smoking), and correlates well with that of the parent isoprostane, 8-iso PGF.2

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Technical Information
Formal Name 9α,11α,15S-trihydroxy-2,3-dinor-(8β)-prosta-5Z,13E-dien-1-oic acid
CAS Number 221664-05-7
  • 2,3-dinor-iPF-III
  • 2,3-dinor-8-iso PGF
Molecular Formula C18H30O5
Formula Weight 326.4
Purity ≥98%
Formulation A solution in methyl acetate
SMILES O[C@@H]1[C@@H](C/C=C\CC(O)=O)[C@@H](/C=C/[C@H](O)CCCCC)[C@H](O)C1
InChI Code 1S/C18H30O5/c1-2-3-4-7-13(19)10-11-15-14(16(20)12-17(15)21)8-5-6-9-18(22)23/h5-6,10-11,13-17,19-21H,2-4,7-9,12H2,1H3,(H,22,23)/b6-5-,11-10+/t13-,14-,15+,16-,17+/m0/s1

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
Stability As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
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Additional Information

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References & Background Reading
Product Description References

1. Morrow, J.D., Hill, K.E., Burk, R.F., et al. A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism. Proc Natl Acad Sci USA 87 9383-9387 (1990).

2. Chiabrando, C., Valagussa, A., Rivalta, C., et al. Identification and measurement of endogenous .beta.-oxidation metabolites of 8-epi-prostaglandin F2a. J Biol Chem 274 1313-1319 (1999).

3. Roberts, L.J., Moore, K.P., Zackert, W.E., et al. Identification of the major urinary metabolite of the F2-isoprostane 8-iso-prostaglandin F2.alpha. in humans. J Biol Chem 271 20617-20620 (1996).

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