8-iso-13,14-dihydro-15-keto Prostaglandin F
Item № 16380
CAS № 191919-02-5
Purity ≥98%
50 µg $62.00 $0.00
100 µg $99.00 $0.00
500 µg $465.00 $0.00
1 mg $868.00 $0.00

Pricing updated 2016-05-01. Prices are subject to change without notice.

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  • 8-iso-13,14-dihydro-15-keto PGF

8-iso-13,14-dihydro-15-keto Prostaglandin F (8-iso-13,14-dihydro-15-keto PGF) is a metabolite of the isoprostane, 8-isoprostane (8-iso PGF), in rabbits, monkeys and humans.1 8-iso PGF is a PG-like product of non-specific lipid peroxidation.2 In both humans and monkeys, exogenously infused 8-isoprostane is converted primarily to metabolites having 2 or 4 carbon atoms removed from the top side chain by β-oxidation.1 A similar pattern is observed when tritiated 8-isoprostane is infused into rabbits.3 Early in the infusion (within 10 minutes) 8-iso-13,14-dihydro-15-keto PGF was a significant component of the metabolite profile, which was comprised mostly of dinor 8-isoprostane metabolites. 8-iso-13,14-dihydro-15-keto PGF weakly inhibits the U-46619 or collagen-induced aggregation of human platelets, although a number of the E-series isoprostanes are much more potent in this assay.4

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Technical Information
Formal Name 9α,11α-dihydroxy-15-oxo-(8β)-prost-5Z-en-1-oic acid
CAS Number 191919-02-5
  • 8-iso-13,14-dihydro-15-keto PGF
Molecular Formula C20H34O5
Formula Weight 354.5
Purity ≥98%
Formulation A solution in methyl acetate
InChI Code 1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,16-19,22-23H,2-3,5-6,8-14H2,1H3,(H,24,25)/b7-4-/t16-,17+,18-,19+/m0/s1

WARNING - This product is not for human or veterinary use.

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Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
Stability As supplied, 1 year from the QC date provided on the Certificate of Analysis, when stored properly
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References & Background Reading
Product Description References

1. Chiabrando, C., Valagussa, A., Rivalta, C., et al. Identification and measurement of endogenous .beta.-oxidation metabolites of 8-epi-prostaglandin F2a. J Biol Chem 274 1313-1319 (1999).

2. Morrow, J.D., Hill, K.E., Burk, R.F., et al. A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism. Proc Natl Acad Sci USA 87 9383-9387 (1990).

3. Basu, S. Metabolism of 8-iso-prostaglandin F2.alpha.. FEBS Lett 428 32-36 (1998).

4. Cranshaw, J.H., Evans, T.W., and Mitchell, J.A. Charcterization of the effects of isoprostanes on platelet aggregation in human whole blood. Br J Pharmacol 132 1699-1706 (2001).

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