Unoprostone isopropyl ester
Item № 16681
CAS № 120373-24-2
Purity ≥98%
1 mg $48.00 $0.00
5 mg $216.00 $0.00
10 mg $384.00 $0.00
50 mg $1,536.00 $0.00

Pricing updated 2016-04-29. Prices are subject to change without notice.

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  • 13,14-dihydro-15-keto-20-ethyl Prostaglandin F isopropyl ester
  • Rescula

Unoprostone isopropyl ester (Rescula) is the clinically approved, prodrug form of unoprostone, which is a free acid analog of prostaglandin F (PGF). Both latanoprost and Rescula have been approved for the treatment of ocular hypertension. Both analogs of PGF are believed to act by increasing the rate of aqueous humor outflow through the uveoscleral pathway.1 Both drugs are believed to act as prodrugs, with endogenous esterases within the eye releasing the free acid active form of the drug. The typical does of Rescula (one drop of 0.12% solution) is nearly 100 times that of latanoprost.2 Rescula has very little activity on isolated DP or TP receptors, less than 0.0005% the activity of PGE2 on EP3 receptors, and about 3% of the activity of PGF on FP receptors.3

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Technical Information
Formal Name 9α,11α-dihydroxy-13,14-dihydro-15-oxo-20a,20b-dihomoprost-5Z-en-1-oic acid, isopropyl ester
CAS Number 120373-24-2
  • 13,14-dihydro-15-keto-20-ethyl Prostaglandin F isopropyl ester
  • Rescula
Molecular Formula C25H44O5
Formula Weight 424.6
Purity ≥98%
Formulation A solution in methyl acetate
InChI Code 1S/C25H44O5/c1-4-5-6-7-10-13-20(26)16-17-22-21(23(27)18-24(22)28)14-11-8-9-12-15-25(29)30-19(2)3/h8,11,19,21-24,27-28H,4-7,9-10,12-18H2,1-3H3/b11-8-/t21-,22-,23+,24-/m1/s1

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
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References & Background Reading
Product Description References

1. Taniguchi, T., Haque, M.S.R., Sugiyama, K., et al. Ocular hypotensive mechanism of topical isopropyl unoprostone, a novel prostaglandin metabolite-related drug, in rabbits. J Ocul Pharmacol 12 489-498 (1996).

2. Haria, M., and Spencer, C.M. Unoprostone (isopropyl unoprostone). Drugs Aging 9 213-218 (1996).

3. Goh, Y., and Kishino, J. Pharmacological characterization of prostaglandin-related ocular hypotensive agents. Jpn J Ophthamol 38 236-245 (1994).

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