AL 8810
Item № 16735
CAS № 246246-19-5
Purity ≥98%
1 mg $84.00 $0.00
5 mg $378.00 $0.00
10 mg $672.00 $0.00
25 mg $1,470.00 $0.00

Pricing updated 2016-05-03. Prices are subject to change without notice.

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AL 8810 is an 11β-fluoro analog of PGF which acts as a potent and selective antagonist at the FP receptor.1 AL 8810 has weak intrinsic agonist activity on FP receptor preparations in the 200-300 nM range, yet it fully antagonizes the activity of the potent FP receptor agonist fluprostenol at this concentration, with EC50 values of approximately 430 nM. AL 8810 fully antagonized the bimatoprost-induced calcium mobilization in Swiss 3T3 fibroblasts at 100 µM, indicating that bimatoprost acts as an FP agonist in this preparation.2 The Ki for the inhibition of several potent agonists at the cloned human ciliary body FP receptor is in the range of 1-2 µM.3

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Technical Information
Formal Name 9α,15R-dihydroxy-11β-fluoro-15-(2,3-dihydro-1H-inden-2-yl)-16,17,18,19,20-pentanor-prosta-5Z,13E-dien-1-oic acid
CAS Number 246246-19-5
Molecular Formula C24H31O4F
Formula Weight 402.5
Purity ≥98%
Formulation A crystalline solid
SMILES O[C@@H]1[C@H](C/C=C\CCCC(O)=O)[C@@H](/C=C/[C@H](O)C2CC3=CC=CC=C3C2)[C@@H](F)C1
InChI Code 1S/C24H31FO4/c25-21-15-23(27)20(9-3-1-2-4-10-24(28)29)19(21)11-12-22(26)18-13-16-7-5-6-8-17(16)14-18/h1,3,5-8,11-12,18-23,26-27H,2,4,9-10,13-15H2,(H,28,29)/b3-1-,12-11+/t19-,20-,21+,22+,23+/m1/s1
License Sold under license from Alcon.

WARNING - This product is not for human or veterinary use.

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Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
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References & Background Reading
Product Description References

1. Griffen, B.W., Klimko, P., Crider, J.Y., et al. AL-8810: A novel prostaglandin F2.alpha. analog with selective antagonist effects at the prostaglandin F2.alpha. (FP) receptor. J Pharmacol Exp Ther 290(3) 1278-1284 (1999).

2. Sharif, N.A., Williams, G.W., and Kelly, C.R. Bimatoprost and its free acid are prostaglandin FP receptor agonists. Eur J Pharmacol 432 211-213 (2001).

3. Sharif, N.A., Kelly, C.R., and Crider, J.Y. Agonist activity of Bimatoprost, Travoprost, Latanoprost, Unoprostone isopropyl ester and other prostaglandin analogs at the cloned human ciliary body FP prostaglandin receptor.. J Ocul Pharmacol 18 313-324 (2002 Feb 27).

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