Latanoprost ethyl amide
Item № 16822
CAS № 607351-44-0
Purity ≥98%
1 mg $53.00 $0.00
5 mg $239.00 $0.00
10 mg $424.00 $0.00

Pricing updated 2016-05-24. Prices are subject to change without notice.

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  • Lat-NEt

Latanoprost ethyl amide (Lat-NEt) is a latanoprost analog in which the C-1 carboxyl group has been modified to an N-ethyl amide. Prostaglandin esters have been shown to have ocular hypotensive activity.1 Prostaglandin N-ethyl amides were recently introduced as alternative prostaglandin ocular hypotensive prodrugs.2 Although it has been claimed that prostaglandin ethyl amides are not converted to the free acids in vivo,3 studies in our laboratories have shown that bovine and human corneal tissue converts the N-ethyl amides of various prostaglandins to the free acids with a conversion rate of about 2.5 µg/g corneal tissue/hr.4 Lat-NEt would be expected to show the typical intraocular effects of Latanoprost free acid, but with the much slower hydrolysis pharmacokinetics of the prostaglandin N-amides.

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Technical Information
Formal Name N-ethyl-9α,11α,15R-trihydroxy-17-phenyl-18,19,20-trinor-prost-5Z-en-1-amide
CAS Number 607351-44-0
  • Lat-NEt
Molecular Formula C25H39NO4
Formula Weight 417.6
Purity ≥98%
Formulation A solution in methyl acetate
SMILES O[C@@H]1[C@H](C/C=C\CCCC(N([H])CC)=O)[C@@H](CC[C@@H](O)CCC2=CC=CC=C2)[C@H](O)C1
InChI Code 1S/C25H39NO4/c1-2-26-25(30)13-9-4-3-8-12-21-22(24(29)18-23(21)28)17-16-20(27)15-14-19-10-6-5-7-11-19/h3,5-8,10-11,20-24,27-29H,2,4,9,12-18H2,1H3,(H,26,30)/b8-3-/t20-,21+,22+,23-,24+/m0/s1

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability As supplied, 1 year from the QC date provided on the Certificate of Analysis, when stored properly
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Additional Information

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References & Background Reading
Product Description References

1. Bito, L.Z. Comparison of the ocular hypotensive efficacy of eicosanoids and related compounds. Exp Eye Res 38 181-184 (1984).

2. Woodward, D.F., Krauss, A.H., Chen, J., et al. The pharmacology of Bimatoprost (Lumigan™). Surv Ophthalmol 45 S337-S345 (2001).

3. Larrouy, D., Vidal, H., Andreelli, F., et al. Cloning and mRNA tissue distribution of human PPAR.gamma. coactivator-1. Int J Obes 23 1327-1332 (1999).

4. Maxey, K.M., Johnson, J., Camras, C.B., et al. The hydrolysis of bimatoprost in corneal tissue generates a potent prostanoid FP receptor agonist. Surv Ophthalmol 47(4) 34-40 (2002).

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