Piriprost (potassium salt)
Item № 18228
CAS № 88851-62-1
Purity ≥98%
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL $0.00
1 mg $41.00 $0.00
5 mg $185.00 $0.00
10 mg $328.00 $0.00
50 mg $1,435.00 $0.00

Pricing updated 2016-05-24. Prices are subject to change without notice.

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Description
Synonyms
  • U-60257B

Piriprost is a structural analog of prostaglandin I2 (PGI2) with low IP receptor-mediated activity. Piriprost inhibits 5-lipoxygenase with an IC50 around 100 µM, as measured by the release of 5-HETE from cultured myometrial cells.1 Piriprost inhibits the release of histamine and leukotrienes from isolated porcine lung cells with an IC50 of 0.11 µM, implicating its role in inflammation and allergic responses.2

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Technical Information
Formal Name 1,4(R),5(R),6-tetrahydro-5-hydroxy-4-[(1E,3S)-3-hydroxy-1-octenyl]-1-phenyl-cyclopenta[b]pyrrole-2-pentanoic acid, monopotassium salt
CAS Number 88851-62-1
Synonyms
  • U-60257B
Molecular Formula C26H34NO4 • K
Formula Weight 463.7
Purity ≥98%
Formulation A crystalline solid
λmax 239 nm
SMILES CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC2=C1C=C(CCCCC([O-])=O)N2C3=CC=CC=C3.[K+]
InChI Code 1S/C26H35NO4.K/c1-2-3-5-13-21(28)15-16-22-23-17-20(12-8-9-14-26(30)31)27(24(23)18-25(22)29)19-10-6-4-7-11-19;/h4,6-7,10-11,15-17,21-22,25,28-29H,2-3,5,8-9,12-14,18H2,1H3,(H,30,31);/q;+1/p-1/b16-15+;/t21-,22+,25+;/m0./s1
InChI Key UFJDMFZMRXDIKI-FFGYHVHASA-M

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability As supplied, 1 year from the QC date provided on the Certificate of Analysis, when stored properly
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Additional Information

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References & Background Reading
Product Description References

1. Cejic, S.S., and Kennedy, T.G. Examination of the effects of piriprost (U-60, 257B) on alkaline phosphatase activity of rat endometrial stromal cells in vitro. Prostaglandins 42 179-189 (1991).

2. McCormack, D.G., and Peterson, N.A.M. The contrasting influence of two lipoxygenase inhibitors on hypoxic pulmonary vasoconstriction in anesthetized pigs. Am Rev Respir Dis 139 100-105 (1989).

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