PAF C-18
Item № 60910
CAS № 74389-69-8
Purity ≥97%
5 mg $50.00 $0.00
10 mg $95.00 $0.00
50 mg $400.00 $0.00
100 mg $700.00 $0.00

Pricing updated 2016-05-25. Prices are subject to change without notice.

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PAF C-18 is a naturally occurring phospholipid produced upon stimulation through two distinct pathways known as the “remodeling” and 'de novo' pathways.1 It is less potent than PAF C-16 in the induction of platelet aggregation, but equipotent in activation of guinea pig macrophages.2 PAF C-18 induces the release of PGE2 and TXB2 from albumin-elicited guinea pig macrophages, and enhances the spreading of plated macrophages.3 Pathological processes involving PAF include necrotizing enterocolitis,4 inflammation, asthma, and allergy.5

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Technical Information
Formal Name 1-O-octadecyl-2-O-acetyl-sn-glyceryl-3-phosphorylcholine
CAS Number 74389-69-8
Molecular Formula C28H58NO7P
Formula Weight 551.7
Purity ≥97%
Formulation A solution in ethanol
InChI Code 1S/C28H58NO7P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-23-33-25-28(36-27(2)30)26-35-37(31,32)34-24-22-29(3,4)5/h28H,6-26H2,1-5H3/t28-/m1/s1

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
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References & Background Reading
Product Description References

1. Prescott, S.M., Zimmerman, G.A., and McIntyre, T.M. Platelet-activating factor. J Biol Chem 265 17381-17384 (1990).

2. Stewart, A.G., and Grigoriadis, G. Structure-activity relationships for platelet-activating factor (PAF) and analogs reveal differences between PAF receptors on platelets and macrophages. J Lipid Mediat 4 299-308 (1991).

3. Hartung, H. Acetyl glyceryl ether phosphorylcholine (platelet-activating factor) mediates heightened metabolic activity in macrophages. Studies on PGE, TXB2 and O2 production, spreading, and the influence of calmodulin-inhibitor W-7. FEBS Lett 160 209-212 (1983).

4. Wang, H., Tan, X., Qu, X., et al. Platelet-activating factor (PAF) up-regulates plasma and tissue PAF-acetylhydrolase activity in the rat: Effect of cycloheximide. Pediatr Res 42 597-603 (1997).

5. Sturk, A., Wouter Ten Cate, J., Hosford, D., et al. The synthesis, catabolism, and pathophysiological role of platelet-activating factor. Adv Lipid Res 23 219-276 (1989).

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