Lyso-PAF C-18
Item № 60916
CAS № 74430-89-0
Purity ≥98%
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL $0.00
5 mg $40.00 $0.00
10 mg $72.00 $0.00
50 mg $240.00 $0.00
100 mg $384.00 $0.00

Pricing updated 2016-05-24. Prices are subject to change without notice.

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Description

Lyso-PAF C-18 can be formed by either the action of PAF-AH on PAF C-181 or by the action of a CoA-independent transacylase on 1-O-octadecyl-2-acyl-glycerophosphocholine.2,3 Lyso PAF C-18 is a substrate for either PAF C-18 formation by the remodeling pathway4 or selective acylation with arachidonic acid by a CoA-independent transacylase.5

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Technical Information
Formal Name 1-O-octadecyl-sn-glyceryl-3-phosphorylcholine
CAS Number 74430-89-0
Molecular Formula C26H56NO6P
Formula Weight 509.7
Purity ≥98%
Formulation A lyophilized powder
SMILES O=P(OCC[N+](C)(C)C)([O-])OC[C@H](O)COCCCCCCCCCCCCCCCCCC
InChI Code 1S/C26H56NO6P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-22-31-24-26(28)25-33-34(29,30)32-23-21-27(2,3)4/h26,28H,5-25H2,1-4H3/t26-/m1/s1
InChI Key XKBJVQHMEXMFDZ-AREMUKBSSA-N

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability As supplied, 1 year from the QC date provided on the Certificate of Analysis, when stored properly
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Additional Information

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References & Background Reading
Product Description References

1. Stafforini, D.M., Prescott, S.M., and McIntyre, T.M. Human plasma platelet-activating factor acetylhydrolase. J Biol Chem 262 4223-4230 (1987).

2. Uemura, Y., Lee, T., and Snyder, F. A coenzyme A-independent transacylase is linked to the formation of platelet-activating factor (PAF) by generating the lyso-PAF intermediate in the remodeling pathway. J Biol Chem 266 8268-8272 (1991).

3. Venable, M.E., Nieto, M.L., Schmitt, J.D., et al. Conversion of 1-O-[3H]alkyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine to lyso platelet-activating factor by the CoA-independent transacylase in membrane fractions of human neutrophils. J Biol Chem 266 18691-18698 (1991).

4. Prescott, S.M., Zimmerman, G.A., and McIntyre, T.M. Platelet-activating factor. J Biol Chem 265 17381-17384 (1990).

5. Venable, M.E., Olson, S.C., Nieto, M.L., et al. Enzymatic studies of lyso platelet-activation factor acylation in human neutrophils and changes upon stimulation. J Biol Chem 268 7965-7975 (1993).

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