D-myo-Inositol-1,3,4-triphosphate (sodium salt)
Item № 60972
Purity ≥98%
100 µg $35.00 $0.00
500 µg $158.00 $0.00
1 mg $280.00 $0.00

Pricing updated 2016-04-29. Prices are subject to change without notice.

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  • Ins(1,3,4)-P3 (sodium salt)
  • 1,3,4-IP3 (sodium salt)

The inositol phosphates play a critical role as small, soluble second messengers in transmission of cellular signals.1,2 D-myo-Inositol-1,3,4-triphosphate (Ins(1,3,4)-P3) is one of several different inositol oligophosphate isomers implicated in signal transduction. Ins(1,3,4)-P3 acts through the inhibition of Ins(3,4,5,6)-P4 kinase activity to increase the cellular level of Ins(3,4,5,6)-P4 and thus inhibit calcium-activated chloride channels.3 The levels of Ins(1,3,4)-P3 are in turn regulated by the levels of cytosolic free calcium.4 The receptor-mediated activation of phospholipase C (PLC) can be seen as the initiating event in this cascade, since PLC generates Ins(1,4,5)-P3 which releases calcium from intracellular storage reservoirs, leading to a dramatic but transient increase in the cytosolic concentration of free calcium.5

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Technical Information
Formal Name D-myo-inositol-1,3,4-tris(dihydrogen phosphate), trisodium salt
  • Ins(1,3,4)-P3 (sodium salt)
  • 1,3,4-IP3 (sodium salt)
Molecular Formula C6H12O15P3 • 3Na
Formula Weight 486.0
Purity ≥98%
Formulation A lyophilized powder
SMILES O[C@H]1[C@@H](OP([O-])(O)=O)[C@H](O)[C@@H](O)[C@H](OP([O-])(O)=O)[C@H]1OP([O-])(O)=O.[Na+].[Na+].[Na+]
InChI Code 1S/C6H15O15P3.3Na/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12;;;/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18);;;/q;3*+1/p-3/t1-,2-,3+,4?,5?,6?;;;/m1.../s1

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
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Additional Information

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References & Background Reading
Product Description References

1. Berridge, M.J. Inositol trisphosphate and calcium signalling. Nature 361 315-325 (1993).

2. Majerus, P.W. Inositol phosphate biochemistry. Annu Rev Biochem 61 225-250 (1992).

3. Yang, X., Rudolf, M., Carew, M.A., et al. Inositol 1,3,4-trisphosphate acts in vivo as a specific regulator of cellular signaling by inositol 3,4,5,6-tetrakisphosphate. J Biol Chem 274 18973-18980 (1999).

4. Lew, P.D., Monod, A., Krause, K., et al. The role of cytosolic free calcium in the generation of inositol 1,4,5-triphosphate and inositol 1,3,4-triphosphate in HL-60 cells. J Biol Chem 261 13121-13127 (1986).

5. Yoshida, Y., and Imai, S. Structure and function of inositol 1,4,5-triphosphate receptor. Jpn J Pharmacol 74 125-137 (1997).

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