Wy 14643
Item № 70730
CAS № 50892-23-4
Purity ≥98%
5 mg $9.00 $0.00
10 mg $17.00 $0.00
50 mg $72.00 $0.00
250 mg $270.00 $0.00

Pricing updated 2016-05-26. Prices are subject to change without notice.

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  • Pirinixic Acid

Wy 14643 is a peroxisome proliferator-activated receptor (PPAR activator). Although this compound is primarily an activator of PPARα,1,2,3 it activates PPARγ as well.4 Activation of PPARδ by Wy 14643 is also observed,5 but this finding is rare. The potency of Wy 14643 as an activator of PPARα is species dependent, with receptor activation occurring at concentrations as low as 0.1 µM in the mouse compared to 10 µM in Xenopus.6

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Technical Information
Formal Name [[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]-acetic acid
CAS Number 50892-23-4
  • Pirinixic Acid
Molecular Formula C14H14ClN3O2S
Formula Weight 323.8
Purity ≥98%
Formulation A crystalline solid
λmax 244, 292 nm
SMILES OC(=O)CSc1nc(cc(Cl)n1)Nc1cccc(C)c1C
InChI Code 1S/C14H14ClN3O2S/c1-8-4-3-5-10(9(8)2)16-12-6-11(15)17-14(18-12)21-7-13(19)20/h3-6H,7H2,1-2H3,(H,19,20)(H,16,17,18)

WARNING - This product is not for human or veterinary use.

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Storage Room temperature
Shipping Room temperature in continental US; may vary elsewhere
Stability As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
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Additional Information

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References & Background Reading
Product Description References

1. Devchand, P.R., Keller, H., Peters, J.M., et al. The PPAR.alpha.-leukotriene B4 pathway to inflammation control. Nature 384 39-43 (1996).

2. Hsu, M., Palmer, C.N.A., Griffin, K.J., et al. A single amino acid change in the mouse peroxisome proliferator-activated receptor .alpha. alters transcriptional responses to peroxisome proliferators. Mol Pharmacol 48 559-567 (1995).

3. Staels, B., Koenig, W., Habib, A., et al. Activation of human aortic smooth-muscle cells is inhibited by PPAR.alpha. but not by PPAR.gamma. activators. Nature 393 790-793 (1998).

4. Lehmann, J.M., Lenhard, J.M., Oliver, B.B., et al. Peroxisome proliferator-activated receptors a and g are activated by indomethacin and other non-steroidal anti-inflammatory drugs. J Biol Chem 272 3406-3410 (1997).

5. Schmidt, A., Endo, N., Rutledge, S.J., et al. Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids. Mol Endocrinol 6 1634-1641 (1992).

6. Keller, H., Devchand, P.R., Perroud, M., et al. PPAR.alpha. structure-function relationships derived from species-specific differences in responsiveness to hypolipidemic agents. Biol Chem 378 651-655 (1997).

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