MEG (sulfate)
Item № 81020
CAS № 3979-00-8
Purity ≥98%
5 mg $55.00 $0.00
10 mg $105.00 $0.00
50 mg $440.00 $0.00
100 mg $770.00 $0.00

Pricing updated 2016-04-30. Prices are subject to change without notice.

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MEG is a selective iNOS inhibitor and scavenger of peroxynitrite. The EC50 values for inhibition of iNOS (LPS-treated rat lung), eNOS (bovine endothelial), and nNOS (rat brain) are 11.5, 110, and 60 µM, respectively.1 MEG reacts with peroxynitrite with a second order rate constant of 1,900 M−1s−1 at 37°C.2 MEG has potent anti-inflammatory activity, which may be due to the combined effect of MEG acting as an inhibitor of iNOS and as a scavenger of peroxynitrite.3

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Technical Information
Formal Name (2-mercaptoethyl)-guanidine sulfate
CAS Number 3979-00-8
Molecular Formula [C3H9N3S]2 · H2SO4
Formula Weight 336.4
Purity ≥98%
Formulation A crystalline solid

WARNING - This product is not for human or veterinary use.

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Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere
Stability As supplied, 1 year from the QC date provided on the Certificate of Analysis, when stored properly
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References & Background Reading
Product Description References

1. Southan, G.J., Zingarelli, B., O'Connor, M., et al. Spontaneous rearrangement of aminoalkylisothioureas into mercaptoalkylguanidines, a novel class of nitric oxide synthase inhibitors with selectivity towards the inducible isoform. Br J Pharmacol 117 619-632 (1996).

2. Szabó, C., Ferrer-Sueta, G., Zingarelli, B., et al. Mercaptoethylguanidine and guanidine inhibitors of nitric-oxide synthase react with peroxynitrite and protect against peroxynitrite-induced oxidative damage. J Biol Chem 272 9030-9036 (1997).

3. Cuzzocrea, S., Zingarelli, B., Hake, P., et al. Antiinflammatory effects of mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, in carrageenan-induced models of inflammation. Free Radic Biol Med 24 450-459 (1998).

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