Dihomo-γ-Linolenic Acid
Item № 90230
CAS № 1783-84-2
Purity ≥98%
10 mg $25.00 $0.00
50 mg $75.00 $0.00
100 mg $95.00 $0.00
500 mg $375.00 $0.00

Pricing updated 2016-05-02. Prices are subject to change without notice.

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  • DGLA
  • cis-8,11,14-Eicosatrienoic acid
  • γ-​Homolinolenic acid

Dihomo-γ-Linolenic Acid (DGLA, 20:3), an elongation product of γ-linolenic acid (18:3), is rapidly metabolized by fatty acid desaturases to produce arachidonic acid (20:4). DGLA is metabolized through the cyclooxygenase pathway to produce 1-series prostaglandins, including PGE1.1,2 In mice, DGLA supplementation in the diet can reduce atopic dermatitis and atherosclerosis.3,4

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Technical Information
Formal Name 8Z,11Z,14Z-eicosatrienoic acid
CAS Number 1783-84-2
  • DGLA
  • cis-8,11,14-Eicosatrienoic acid
  • γ-​Homolinolenic acid
Molecular Formula C20H34O2
Formula Weight 306.5
Purity ≥98%
Formulation A solution in ethanol
InChI Code 1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability As supplied, 1 year from the QC date provided on the Certificate of Analysis, when stored properly
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Additional Information

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References & Background Reading
Product Description References

1. Bell, J.G., Tocher, D.R., and Sargent, J.R. Effect of supplementation with 20:3(n-3), 20:4(n-6) and 20:5(n-3) on the production of prostaglandins E and F of the 1-, 2- and 3-series in turbot (Scophthalmus maximus) brain astroglial cells in primary culture. Biochim Biophys Acta 1211 335-342 (1994).

2. Levin, G., Duffin, K.L., Obukowicz, M.G., et al. Differential metabolism of dihomo-.gamma.-linolenic acid and arachidonic acid by cyclo-oxygenase-1 and cyclo-oxygenase-2: Implications for cellular synthesis of prostaglandin E1 and prostaglandin E2. Biochem J 365 489-496 (2002).

3. Kawashima, H., Tateishi, N., Shiraishi, A., et al. Oral administration of dihomo-.gamma.-linolenic acid prevents development of atopic dermatitis in NC/Nga mice. Lipids 43(1) 37-43 (2007).

4. Takai, S., Jin, D., Kawashima, H., et al. Anti-atherosclerotic effects of dihomo-.gamma.-linolenic acid in ApoE-deficient mice. J Atheroscer Thromb 16(4) 480-489 (2009).

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