(USA and Canada Only)
Cayman Contract Services provides discovery and pre-clinical development services to the global pharmaceutical, biotechnology, and academic research markets. Our diverse suite of services leverages a team of over 150 highly skilled scientists with expertise in medicinal chemistry, structure-based drug design, complex multi-step organic synthesis, analytical chemistry, sample analysis, and custom assay development. We offer a personalized, flexible approach that enables our clients to accelerate their drug discovery and development through a single-source partner, from novel drug design and synthesis to target identification and validation.
Our Contract Services division provides expertise in:
Email us at contractresearch@caymanchem.com
Call us at (888) 526-5351
Fill out the form below.
Cayman’s Bioanalytical Division offers a wide range of services to accelerate discovery and pre-clinical development initiatives. Our scientific staff has decades of industry expertise in assay and methods development, sample preparation, and analysis. We consult with you from project kickoff to conclusion on experimental design and data analysis to ensure you meet your objectives. Select from our catalog of well-characterized assays, qualified commercially available assays, or let our experts design a custom assay that suits your specific requirements. Our team regularly develops plate-based, mass spectrometry-based, cell-based, and flow cytometry assays.
Sample Analysis
Biomarker profiling
Activity screening
Lipidomic profiling
Poster: Lipidomics in Cells, Plasma, and Tissues (PDF)
Immunopeptidome profiling
Proteomic profiling and PTM analysis
Mitochondrial/bioenergetics profiling
Custom Assay Development
Immunoassays
Mass spectrometry-based assays
Application Note: Use of a Novel Method of Derivatization to Improve LC-MS/MS Sensitivity of 1,3-Dienes (PDF)
Enzyme activity assays
Cell-based assays
Reporter assays
Email us at contractresearch@caymanchem.com
Call us at (888) 526-5351
Fill out the form below.
The Medicinal Chemistry and Structural Biology groups at Cayman have successfully delivered on a wide range of external drug development programs and driven independent and collaborative external and internal programs. This service offers a fully integrated multidisciplinary approach from design and synthesis to screening and optimization. Scale-up and process/GMP development are also offered. Whether it’s lead generation or optimization, route and methods development, screening, or scale-up, Cayman’s experienced medicinal and organic chemists, structural biologists, and biochemists possess the competencies to augment your pre-clinical drug discovery and development needs.
Drug Design, SAR, & Process Scaling
In silico drug design and selectivity assessment
Poster: A Novel Series of Selective Agonists Evaluated Against Rattus Norvegicus EP4 Receptor (PDF)
Application Note (with expanded results section): A Novel Series of Selective Agonists Evaluated Against Rattus Norvegicus EP4 Receptor (PDF)
Parallel library generation
Structure-activity relationship studies
Lead optimization and development
Route development and scale-up
Pre-GMP process development
Structural Biology
Recombinant protein production and characterization
Biophysical characterization and optimization
Protein crystallization
Structure determination by X-ray crystallography
Case Study: Designing Small Molecule Inhibitors for Autotaxin (PDF)
In silico docking and homology modeling
Email us at contractresearch@caymanchem.com
Call us at (888) 526-5351
Fill out the form below.
Our scientists perform routine quality control testing on thousands of compounds each year, giving Cayman unparalleled expertise in the development and validation of methods to analyze, quantify, and purify small molecules. Employing multiple chemical testing methods customized to each project’s unique requirements, we perform qualitative and quantitative analysis, purification, and characterization of chemical entities such as bioactive lipids, natural products, synthetic compounds, cosmetics, pharmaceuticals, and drugs of abuse in organic and biological matrices.
Purification and characterization
Preparative HPLC
Analytical HPLC
Mass spectrometry (LC-MS, GC-MS)
NMR (1H, 13C, 19F, 2D)
Karl Fischer testing
Sample Analysis
Solubility
Metabolism
Rate of release
Pharmacokinetics testing
De-formulation Testing
Active ingredient determination
Impurity limit testing
Homogeneity and stability testing
Email us at contractresearch@caymanchem.com
Call us at (888) 526-5351
Fill out the form below.
Our team of synthetic organic and medicinal chemists brings decades of academic and pharmaceutical experience to perform complex, multi-step organic syntheses. Supported by our Medicinal Chemistry & Structure-Based Drug Design and GMP & Process Development Services, our growing team of more than 70 highly skilled organic chemists has added broad synthetic proficiencies to our traditional core expertise in lipid, bioconjugate, and stable isotope labeling chemistry. We are ready to take on your next challenging project!
Classic and Emerging Drugs of Abuse including PEDs, LSD, Amphetamines, Benzodiazepines, Synthetic Cannabinoids, Opioids, and more
PUFAs, Eicosanoids, Glycerides, and Polar Lipids
Small Molecule, Drug-like Heterocyclic Compounds
Stable Isotope-labeled Target Standards
Small Molecule Analog Synthesis/SAR, Parallel Medicinal Chemistry, and Compound Library Generation
Hit-to-Lead: Iterative Design, Synthesis, and Screening
Lead Optimization and Scale-up
Specialized Syntheses
Bioconjugation
Fluorescent Dye Design, Development, and Synthesis
Selective, Stable Isotopic Labeling
Natural Product Chemistry: Extraction from Biological Sources and Total Synthesis
GMP & Process Development
Chemical Route Exploration, Development, and Optimization
Preclinical/Clinical API Synthesis and Method Validation
Commercial GMP-API Manufacturing
Analytical Standards
Reference Materials
Certified Reference Materials
Email us at contractresearch@caymanchem.com
Call us at (888) 526-5351
Fill out the form below.
Bioanalysis services for the characterization of peptides associated with the major histocompatibility complex.
1180 East Ellsworth Road
Ann Arbor, Michigan 48108 USA
Copyright 2019 Cayman Chemical
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