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Join us! · ENDO 2015 · San Diego, California · March 5-8, 2015 · Booth 1935
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Cayman is a manufacturer, supplier, and vendor of biochemical reagents, assay kits, forensic chemistry standards, antibodies, and proteins for scientific research. Analytical testing services and custom synthesis are also available.

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

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Figure 2. Biosynthesis of PGE2

From Alzheimer's Disease and Arachidonic Acid by Brock, T.G.

cPLA2 is an AA-selective enzyme that releases this PUFA from membrane phospholipids in response to Aβ. Free AA is metabolized by constitutively-expressed COX-1 and inducible COX-2 to the intermediate PGH2. The synthesis of PGE2 is completed by PGES, including cPGES, mPGES-1, and mPGES-2. NSAIDs inhibit both forms of COX, while coxibs selectively inhibit COX-2.

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