Figure 2. Biosynthesis of PGE2

From Alzheimer's Disease and Arachidonic Acid by Brock, T.G.

cPLA2 is an AA-selective enzyme that releases this PUFA from membrane phospholipids in response to Aβ. Free AA is metabolized by constitutively-expressed COX-1 and inducible COX-2 to the intermediate PGH2. The synthesis of PGE2 is completed by PGES, including cPGES, mPGES-1, and mPGES-2. NSAIDs inhibit both forms of COX, while coxibs selectively inhibit COX-2.

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