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Mojo Item № Product Image Plain Text Name Synonyms Keywords
85.272430939226 10784 PAD1 (human recombinant)

Active, pure human recombinant enzyme

Protein Arginine Deiminases (PADs) are guanidino-modifying enzymes belonging to the amidinotransferase superfamily and are designated PAD1-4 and PAD6. PADs are calcium-dependent enzymes that catalyze the post-translational modification of target proteins by converting arginine to citrulline . The various PADs exhibit tissue specific expression and different subcellular localization. PAD1 is expressed in uterus and throughout the epidermis. PAD1 and PAD3 are speculated to mediate deimination of epidermal filaggrin (filament aggregation protein) and keratins, proteins involved in maintaining skin hydration.

pad1-human-recombinant Protein-Arginine Deiminase 1; PDI1; ​PADI1 PAD1 PADI-1 arginine deiminase post-translational modifications citrullination skin keratinocytes calcium-dependent active
131.532578268876 10500 PAD4 (human recombinant)

Active, pure human recombinant enzyme

Protein Arginine Deiminases (PADs) are guanidino-modifying enzymes belonging to the amidinotransferase superfamily and are designated PAD1-4 and PAD6. All enzymes are cytosolic except for PAD4 which is localized in the nucleus. PAD4 is a homodimer that functions as a transcriptional coregulator to catalyze the conversion of specific arginine residues to citrulline in a calcium-dependent manner. PAD4 substrates include histones H2A, H3, and H4, whose post-translational modifications play a large role in gene regulation. Benzoylated arginine substrates like N-α-Benzoyl-L-arginine ethyl ester (BAEE) have proven to be useful tools for characterization of PAD4, having similar kinetic properties to the natural substrates. PAD4 itself can undergo autocitrullination at several sites, which inhibits its enzymatic activity and may play an important role in regulating citrullination in cells. PAD4 activity is increased in rheumatoid arthritis, producing an abundance of citrulline-containing proteins that can be recognized by autoantibodies, which cause the immune system to attack its own tissues. PAD4 has also been implicated in several other diseases including multiple sclerosis, Alzheimer’s disease, glaucoma, and cancer.

pad4-human-recombinant Protein Arginine Deiminase 4; PADI4; Peptidylarginine Deiminase 4; PADI5; PDI5 guanidino modifying enzymes citrillination histones deiminase MS multiple sclerosis Alzheimer's diseases glaucoma IOP intraocular pressure cancers peptidylarginine deiminase active genes regulations
61.040932851678 700560 PAD4 Inhibitor Screening Assay Kit

A convenient method for screening human PAD4 inhibitors

Protein Arginine Deiminase 4 (PAD4) is a guanidino-modifying enzyme that functions as a transcriptional coregulator catalyzing the conversion of specific arginine residues to citrulline. Substrates for PAD4 include histones H2A, H3, and H4. PAD4 autocitrullinates itself at several sites, inhibiting its enzymatic activity. PAD4 activity is increased in rheumatoid arthritis, producing an abundance of citrulline-containing proteins that generate an immune response resulting in production of autoantibodies that ultimately attack the host tissues. PAD4 has also been implicated in several other diseases including multiple sclerosis, Alzheimer’s disease, glaucoma, and cancer. Cayman’s PAD4 Inhibitor Screening Assay provides a convenient, fluorescence-based method for screening human PAD4 inhibitors.

pad4-inhibitor-screening-assay-kit Peptidylarginine Deiminase 4; Protein Arginine Deiminase 4; PADI4; PADI5; PDI5 kits assays measures measurements proteins arginines deiminases PADs guanidine-modifying enzymes peptidylarginine deiminase amidinotransferases nucleus homodimers transcriptional coregulator catalyzes residues citrulline calcium-dependent substrates histones H2A H3 H4 post-translational modifications genes regulations autocitrullination inhibits enzymatic activity cells rheumatoid arthritis citrulline-containing immune response autoantibodies tissues multiple sclerosis Alzheimer's diseases glaucoma cancers human deiminates N-α-benzoyl-L-arginine ethyl esters BAEE kinetic ammonia detectors fluorescent fluorescence

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA

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